{"code":"D81.82","type":"code","title":"Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]","codeAlso":[", if applicable, any associated manifestations, such as:","bronchiectasis (J47.-)","herpes virus infections (B00.-)","other acute respiratory tract infections (J00-J06; J20-J22)","other infections (A00-B99)","pneumonia (J12-J18)"],"includes":["defects in the complement system","immunodeficiency disorders, except human immunodeficiency virus [HIV] disease","sarcoidosis"],"modern_v":"official26","codeFirst":[],"excludes1":["autosomal recessive agammaglobulinemia (Swiss type) (D80.0)","autoimmune disease (systemic) NOS (M35.9)","functional disorders of polymorphonuclear neutrophils (D71-)"],"excludes2":["human immunodeficiency virus [HIV] disease (B20)"],"isBillable":true,"fyEffectivity":{"fy2026":true,"fy2027":true,"billableFy2026":true,"billableFy2027":true},"inclusionTerms":["p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease"],"useAdditionalCode":[],"clinicalDefinition":"Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] is a billable ICD-10-CM diagnosis code (D81.82). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease. Excludes1 (not coded here): autosomal recessive agammaglobulinemia (Swiss type) (D80.0); autoimmune disease (systemic) NOS (M35.","officialDefinition":"Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] is a billable ICD-10-CM diagnosis code (D81.82). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease. Excludes1 (not coded here): autosomal recessive agammaglobulinemia (Swiss type) (D80.0); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Code also: , if applicable, any associated manifestations, such as:; bronchiectasis (J47.-); herpes virus infections (B00.-); other acute respiratory tract infections (J00-J06; J20-J22); other infections (A00-B99); pneumonia (J12-J18).","seventhCharacterInstructions":[],"workflowProtocols":[],"guidelines":{"whenToUse":[],"whenNotToUse":[],"commonBillingMistakes":[],"codeComparisons":[],"documentationChecklist":[]},"domainLandscape":{"summary":"Primary diagnostic domain and clinical landscape evaluation.","keyCategories":[],"diagnosticContinuum":"Progression continuum from acute presentation to resolution."},"children":[],"hierarchy":[],"relatedCodes":[],"relevantCPTCodes":[],"documentationTips":[],"caseStudies":[],"description":"","overview":""}