{"code":"D89","type":"category","title":"Other disorders involving the immune mechanism, not elsewhere classified","codeAlso":[],"includes":["defects in the complement system","immunodeficiency disorders, except human immunodeficiency virus [HIV] disease","sarcoidosis"],"modern_v":"official26","codeFirst":[],"excludes1":["hyperglobulinemia NOS (R77.1)","monoclonal gammopathy (of undetermined significance) (D47.2)","autoimmune disease (systemic) NOS (M35.9)","functional disorders of polymorphonuclear neutrophils (D71-)"],"excludes2":["transplant failure and rejection (T86.-)","human immunodeficiency virus [HIV] disease (B20)"],"isBillable":false,"fyEffectivity":{"fy2026":true,"fy2027":true,"billableFy2026":false,"billableFy2027":false},"sibling_codes":["D89.0","D89.1","D89.2","D89.3","D89.4","D89.8","D89.810","D89.811","D89.812","D89.813","D89.831","D89.832","D89.833","D89.834","D89.835","D89.839","D89.9"],"inclusionTerms":[],"sibling_titles":{"code":"D89.9","title":"Disorder involving the immune mechanism, unspecified","isBillable":true},"useAdditionalCode":[],"clinicalDefinition":"Other disorders involving the immune mechanism, not elsewhere classified is a non-billable ICD-10-CM category code (D89). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.","officialDefinition":"Other disorders involving the immune mechanism, not elsewhere classified is a non-billable ICD-10-CM category code (D89). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","seventhCharacterInstructions":[],"workflowProtocols":[],"guidelines":{"whenToUse":[],"whenNotToUse":[],"commonBillingMistakes":[],"codeComparisons":[],"documentationChecklist":[]},"domainLandscape":{"summary":"Primary diagnostic domain and clinical landscape evaluation.","keyCategories":[],"diagnosticContinuum":"Progression continuum from acute presentation to resolution."},"children":[{"code":"D89.0","title":"Polyclonal hypergammaglobulinemia","description":"Polyclonal hypergammaglobulinemia is a billable ICD-10-CM diagnosis code (D89.0). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Benign hypergammaglobulinemic purpura; Polyclonal gammopathy NOS. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.0-polyclonal-hypergammaglobulinemia"},{"code":"D89.1","title":"Cryoglobulinemia","description":"Cryoglobulinemia is a billable ICD-10-CM diagnosis code (D89.1). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Cryoglobulinemic purpura; Cryoglobulinemic vasculitis; Essential cryoglobulinemia; Idiopathic cryoglobulinemia; Mixed cryoglobulinemia; Primary cryoglobulinemia; Secondary cryoglobulinemia. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.1-cryoglobulinemia"},{"code":"D89.2","title":"Hypergammaglobulinemia, unspecified","description":"Hypergammaglobulinemia, unspecified is a billable ICD-10-CM diagnosis code (D89.2). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.2-hypergammaglobulinemia-unspecified"},{"code":"D89.3","title":"Immune reconstitution syndrome","description":"Immune reconstitution syndrome is a billable ICD-10-CM diagnosis code (D89.3). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Immune reconstitution inflammatory syndrome [IRIS]. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Use additional code: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).","isBillable":true,"slug":"d89.3-immune-reconstitution-syndrome"},{"code":"D89.4","title":"Mast cell activation syndrome and related disorders","description":"Mast cell activation syndrome and related disorders is a non-billable ICD-10-CM category code (D89.4). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":false,"slug":"d89.4-mast-cell-activation-syndrome-and-related-disorders"},{"code":"D89.40","title":"Mast cell activation, unspecified","description":"Mast cell activation, unspecified is a billable ICD-10-CM diagnosis code (D89.40). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Mast cell activation disorder, unspecified; Mast cell activation syndrome, NOS. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.40-mast-cell-activation-unspecified"},{"code":"D89.41","title":"Monoclonal mast cell activation syndrome","description":"Monoclonal mast cell activation syndrome is a billable ICD-10-CM diagnosis code (D89.41). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.41-monoclonal-mast-cell-activation-syndrome"},{"code":"D89.42","title":"Idiopathic mast cell activation syndrome","description":"Idiopathic mast cell activation syndrome is a billable ICD-10-CM diagnosis code (D89.42). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.42-idiopathic-mast-cell-activation-syndrome"},{"code":"D89.43","title":"Secondary mast cell activation","description":"Secondary mast cell activation is a billable ICD-10-CM diagnosis code (D89.43). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Secondary mast cell activation syndrome. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code also: underlying etiology, if known.","isBillable":true,"slug":"d89.43-secondary-mast-cell-activation"},{"code":"D89.44","title":"Hereditary alpha tryptasemia","description":"Hereditary alpha tryptasemia is a billable ICD-10-CM diagnosis code (D89.44). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Use additional code: code, if applicable, for:; allergy status, other than to drugs and biological substances (Z91.0-); personal history of anaphylaxis (Z87.892).","isBillable":true,"slug":"d89.44-hereditary-alpha-tryptasemia"},{"code":"D89.49","title":"Other mast cell activation disorder","description":"Other mast cell activation disorder is a billable ICD-10-CM diagnosis code (D89.49). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Other mast cell activation syndrome. Excludes1 (not coded here): aggressive systemic mastocytosis (C96.21); congenital cutaneous mastocytosis (Q82.2); (non-congenital) cutaneous mastocytosis (D47.01); (indolent) systemic mastocytosis (D47.02); malignant mast cell neoplasm (C96.2-); malignant mastocytoma (C96.29); mast cell leukemia (C94.3-); mast cell sarcoma (C96.22); mastocytoma NOS (D47.09); other mast cell neoplasms of uncertain behavior (D47.09); systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.49-other-mast-cell-activation-disorder"},{"code":"D89.8","title":"Other specified disorders involving the immune mechanism, not elsewhere classified","description":"Other specified disorders involving the immune mechanism, not elsewhere classified is a non-billable ICD-10-CM category code (D89.8). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":false,"slug":"d89.8-other-specified-disorders-involving-the-immune-mechanism-not-elsewhere-classified"},{"code":"D89.81","title":"Graft-versus-host disease","description":"Graft-versus-host disease is a non-billable ICD-10-CM category code (D89.81). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89). Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17); hair loss (L65.9).","isBillable":false,"slug":"d89.81-graft-versus-host-disease"},{"code":"D89.810","title":"Acute graft-versus-host disease","description":"Acute graft-versus-host disease is a billable ICD-10-CM diagnosis code (D89.810). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89). Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17); hair loss (L65.9).","isBillable":true,"slug":"d89.810-acute-graft-versus-host-disease"},{"code":"D89.811","title":"Chronic graft-versus-host disease","description":"Chronic graft-versus-host disease is a billable ICD-10-CM diagnosis code (D89.811). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89). Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17); hair loss (L65.9).","isBillable":true,"slug":"d89.811-chronic-graft-versus-host-disease"},{"code":"D89.812","title":"Acute on chronic graft-versus-host disease","description":"Acute on chronic graft-versus-host disease is a billable ICD-10-CM diagnosis code (D89.812). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89). Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17); hair loss (L65.9).","isBillable":true,"slug":"d89.812-acute-on-chronic-graft-versus-host-disease"},{"code":"D89.813","title":"Graft-versus-host disease, unspecified","description":"Graft-versus-host disease, unspecified is a billable ICD-10-CM diagnosis code (D89.813). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89). Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17); hair loss (L65.9).","isBillable":true,"slug":"d89.813-graft-versus-host-disease-unspecified"},{"code":"D89.82","title":"Autoimmune lymphoproliferative syndrome [ALPS]","description":"Autoimmune lymphoproliferative syndrome [ALPS] is a billable ICD-10-CM diagnosis code (D89.82). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.82-autoimmune-lymphoproliferative-syndrome-alps"},{"code":"D89.83","title":"Cytokine release syndrome","description":"Cytokine release syndrome is a non-billable ICD-10-CM category code (D89.83). A more specific billable subcode must be selected for claims submission. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":false,"slug":"d89.83-cytokine-release-syndrome"},{"code":"D89.831","title":"Cytokine release syndrome, grade 1","description":"Cytokine release syndrome, grade 1 is a billable ICD-10-CM diagnosis code (D89.831). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.831-cytokine-release-syndrome-grade-1"},{"code":"D89.832","title":"Cytokine release syndrome, grade 2","description":"Cytokine release syndrome, grade 2 is a billable ICD-10-CM diagnosis code (D89.832). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.832-cytokine-release-syndrome-grade-2"},{"code":"D89.833","title":"Cytokine release syndrome, grade 3","description":"Cytokine release syndrome, grade 3 is a billable ICD-10-CM diagnosis code (D89.833). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.833-cytokine-release-syndrome-grade-3"},{"code":"D89.834","title":"Cytokine release syndrome, grade 4","description":"Cytokine release syndrome, grade 4 is a billable ICD-10-CM diagnosis code (D89.834). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.834-cytokine-release-syndrome-grade-4"},{"code":"D89.835","title":"Cytokine release syndrome, grade 5","description":"Cytokine release syndrome, grade 5 is a billable ICD-10-CM diagnosis code (D89.835). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.835-cytokine-release-syndrome-grade-5"},{"code":"D89.839","title":"Cytokine release syndrome, grade unspecified","description":"Cytokine release syndrome, grade unspecified is a billable ICD-10-CM diagnosis code (D89.839). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-). Code first: underlying cause, such as:; complications following infusion, transfusion and therapeutic injection (T80.89-); complications of transplanted organs and tissue (T86.-). Use additional code: code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5); code to identify associated manifestations.","isBillable":true,"slug":"d89.839-cytokine-release-syndrome-grade-unspecified"},{"code":"D89.84","title":"IgG4-related disease","description":"IgG4-related disease is a billable ICD-10-CM diagnosis code (D89.84). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Immunoglobulin G4-related disease. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.84-igg4-related-disease"},{"code":"D89.89","title":"Other specified disorders involving the immune mechanism, not elsewhere classified","description":"Other specified disorders involving the immune mechanism, not elsewhere classified is a billable ICD-10-CM diagnosis code (D89.89). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Excludes1 (not coded here): human immunodeficiency virus disease (B20); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.89-other-specified-disorders-involving-the-immune-mechanism-not-elsewhere-classified"},{"code":"D89.9","title":"Disorder involving the immune mechanism, unspecified","description":"Disorder involving the immune mechanism, unspecified is a billable ICD-10-CM diagnosis code (D89.9). Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus [HIV] disease; sarcoidosis. Inclusion terms: Immune disease NOS. Excludes1 (not coded here): hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-); human immunodeficiency virus [HIV] disease (B20). Excludes2 (not included here): transplant failure and rejection (T86.-).","isBillable":true,"slug":"d89.9-disorder-involving-the-immune-mechanism-unspecified"}],"hierarchy":[],"relatedCodes":[],"relevantCPTCodes":[],"documentationTips":[],"caseStudies":[],"description":"","overview":""}