E08.21 is the authoritative medical code for Diabetes mellitus due to underlying condition with diabetic nephropathy. This classification is used in medical billing and clinical recording to specify the clinical criteria for diabetes mellitus due to underlying condition with diabetic nephropathy (ICD-10-CM E08.21), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Diabetes mellitus due to underlying condition with diabetic nephropathy is a billable ICD-10-CM diagnosis code E08.21. Inclusion terms: Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis; Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis; Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease. Excludes1 (not coded here): drug or chemical induced diabetes mellitus E09.-; gestational diabetes O24.4-; neonatal diabetes mellitus P70.2; postpancreatectomy diabetes mellitus E13.-; postprocedural diabetes mellitus E13.-; secondary diabetes mellitus NEC E13.-; type 1 diabetes mellitus E10.-; type 2 diabetes mellitus E11.-. Code first: the underlying condition, such as:; congenital rubella P35.0; Cushing's syndrome E24.-; cystic fibrosis E84.-; malignant neoplasm C00-C96; malnutrition E40-E46; pancreatitis and other diseases of the pancreas K85-K86.-. Use additional code: code to identify control using:; injectable non-insulin antidiabetic drugs Z79.85; insulin Z79.4; oral antidiabetic drugs Z79.84; oral hypoglycemic drugs Z79.84.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for E08.21 in the official ICD-10-CM tabular list.
Inclusion Terms
Alternative terms the tabular list files under this code.
- Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis
- Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
- Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- drug or chemical induced diabetes mellitus E09.-
- gestational diabetes O24.4-
- neonatal diabetes mellitus P70.2
- postpancreatectomy diabetes mellitus E13.-
- postprocedural diabetes mellitus E13.-
- secondary diabetes mellitus NEC E13.-
- type 1 diabetes mellitus E10.-
- type 2 diabetes mellitus E11.-
Code First
Underlying conditions that must be sequenced before this code.
- the underlying condition, such as:
- congenital rubella P35.0
- Cushing's syndrome E24.-
- cystic fibrosis E84.-
- malignant neoplasm C00-C96
- malnutrition E40-E46
- pancreatitis and other diseases of the pancreas K85-K86.-
Use Additional Code
Supplementary codes the tabular list directs you to add.
- code to identify control using:
- injectable non-insulin antidiabetic drugs Z79.85
- insulin Z79.4
- oral antidiabetic drugs Z79.84
- oral hypoglycemic drugs Z79.84
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with E08.21?
Per Excludes1 instructions, E08.21 must not be reported with: drug or chemical induced diabetes mellitus (E09.-); gestational diabetes (O24.4-); neonatal diabetes mellitus (P70.2); postpancreatectomy diabetes mellitus (E13.-).
Does E08.21 need to be sequenced after another code?
Yes. Code first: the underlying condition, such as:; congenital rubella (P35.0); Cushing's syndrome (E24.-); cystic fibrosis (E84.-).
Is an additional code needed with E08.21?
Use additional code(s) to specify: code to identify control using:; injectable non-insulin antidiabetic drugs (Z79.85); insulin (Z79.4); oral antidiabetic drugs (Z79.84).
What conditions are included under E08.21?
Diabetes mellitus due to underlying condition with diabetic nephropathy includes: Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis; Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis; Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease.
Codes in This Family (40)
Official ICD-10-CM classifications in the same code family as E08.21, with their registry titles.
- E08 — Diabetes mellitus due to underlying condition
- E08.0 — Diabetes mellitus due to underlying condition with hyperosmolarity
- E08.01 — Diabetes mellitus due to underlying condition with hyperosmolarity with coma
- E08.1 — Diabetes mellitus due to underlying condition with ketoacidosis
- E08.10 — Diabetes mellitus due to underlying condition with ketoacidosis without coma
- E08.11 — Diabetes mellitus due to underlying condition with ketoacidosis with coma
- E08.2 — Diabetes mellitus due to underlying condition with kidney complications
- E08.22 — Diabetes mellitus due to underlying condition with diabetic chronic kidney disease
- E08.29 — Diabetes mellitus due to underlying condition with other diabetic kidney complication
- E08.3 — Diabetes mellitus due to underlying condition with ophthalmic complications
- E08.31 — Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy
- E08.311 — Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema
- E08.319 — Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema
- E08.32 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy
- E08.321 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema
- E08.3211 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3212 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3213 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, bilateral
- E08.3219 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, unspecified eye
- E08.329 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema
- E08.3291 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, right eye
- E08.3292 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, left eye
- E08.3293 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, bilateral
- E08.3299 — Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema, unspecified eye
- E08.33 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy
- E08.331 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema
- E08.3311 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3312 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3313 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, bilateral
- E08.3319 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema, unspecified eye
- E08.339 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema
- E08.3391 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, right eye
- E08.3392 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, left eye
- E08.3393 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, bilateral
- E08.3399 — Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema, unspecified eye
- E08.34 — Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy
- E08.341 — Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema
- E08.3411 — Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, right eye
- E08.3412 — Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, left eye
- E08.3413 — Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema, bilateral
Indexed Clinical Terms (4)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, glomerulonephrosis, intracapillary
- Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, glomerulosclerosis, intercapillary
- Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, Kimmelstiel-Wilson disease
- Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, nephropathy
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:
ICD Code E05.21
Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
ICD Code E09.21
Drug or chemical induced diabetes mellitus with diabetic nephropathy
ICD Code E13.21
Other specified diabetes mellitus with diabetic nephropathy