F11.221 is the authoritative medical code for Opioid dependence with intoxication delirium. This classification is used in medical billing and clinical recording to specify the clinical criteria for opioid dependence with intoxication delirium (ICD-10-CM F11.221), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Opioid dependence with intoxication delirium is a billable ICD-10-CM diagnosis code F11.221. Excludes1 (not coded here): opioid dependence with withdrawal F11.23; opioid abuse F11.1-; opioid use, unspecified F11.9-. Excludes2 (not included here): opioid poisoning T40.0-T40.2-.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for F11.221 in the official ICD-10-CM tabular list.
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- opioid dependence with withdrawal F11.23
- opioid abuse F11.1-
- opioid use, unspecified F11.9-
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- opioid poisoning T40.0-T40.2-
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with F11.221?
Per Excludes1 instructions, F11.221 must not be reported with: opioid dependence with withdrawal (F11.23); opioid abuse (F11.1-); opioid use, unspecified (F11.9-).
Can F11.221 be reported alongside related conditions?
Per Excludes2 instructions, F11.221 and the following may both be reported when both are present: opioid poisoning (T40.0-T40.2-).
Codes in This Family (40)
Official ICD-10-CM classifications in the same code family as F11.221, with their registry titles.
- F11 — Opioid related disorders
- F11.1 — Opioid abuse
- F11.10 — Opioid abuse, uncomplicated
- F11.11 — Opioid abuse, in remission
- F11.12 — Opioid abuse with intoxication
- F11.120 — Opioid abuse with intoxication, uncomplicated
- F11.121 — Opioid abuse with intoxication delirium
- F11.122 — Opioid abuse with intoxication with perceptual disturbance
- F11.129 — Opioid abuse with intoxication, unspecified
- F11.13 — Opioid abuse with withdrawal
- F11.14 — Opioid abuse with opioid-induced mood disorder
- F11.15 — Opioid abuse with opioid-induced psychotic disorder
- F11.150 — Opioid abuse with opioid-induced psychotic disorder with delusions
- F11.151 — Opioid abuse with opioid-induced psychotic disorder with hallucinations
- F11.159 — Opioid abuse with opioid-induced psychotic disorder, unspecified
- F11.18 — Opioid abuse with other opioid-induced disorder
- F11.181 — Opioid abuse with opioid-induced sexual dysfunction
- F11.182 — Opioid abuse with opioid-induced sleep disorder
- F11.188 — Opioid abuse with other opioid-induced disorder
- F11.19 — Opioid abuse with unspecified opioid-induced disorder
- F11.2 — Opioid dependence
- F11.20 — Opioid dependence, uncomplicated
- F11.21 — Opioid dependence, in remission
- F11.22 — Opioid dependence with intoxication
- F11.220 — Opioid dependence with intoxication, uncomplicated
- F11.222 — Opioid dependence with intoxication with perceptual disturbance
- F11.229 — Opioid dependence with intoxication, unspecified
- F11.23 — Opioid dependence with withdrawal
- F11.24 — Opioid dependence with opioid-induced mood disorder
- F11.25 — Opioid dependence with opioid-induced psychotic disorder
- F11.250 — Opioid dependence with opioid-induced psychotic disorder with delusions
- F11.251 — Opioid dependence with opioid-induced psychotic disorder with hallucinations
- F11.259 — Opioid dependence with opioid-induced psychotic disorder, unspecified
- F11.28 — Opioid dependence with other opioid-induced disorder
- F11.281 — Opioid dependence with opioid-induced sexual dysfunction
- F11.282 — Opioid dependence with opioid-induced sleep disorder
- F11.288 — Opioid dependence with other opioid-induced disorder
- F11.29 — Opioid dependence with unspecified opioid-induced disorder
- F11.9 — Opioid use, unspecified
- F11.90 — Opioid use, unspecified, uncomplicated
Indexed Clinical Terms (3)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Delirium, delirious (acute or subacute) (not alcohol- or drug-induced), due to (secondary to), opioid intoxication (acute), in, dependence
- Dependence (on) (syndrome), drug NEC, opioid, with, intoxication, with, delirium
- Disorder (of), opioid use, moderate or severe, with, opioid intoxication, delirium
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:
ICD Code F13.221
Sedative, hypnotic or anxiolytic dependence with intoxication delirium