T46 is the authoritative medical code for Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system. This classification is used in medical billing and clinical recording to specify the clinical criteria for poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (ICD-10-CM T46), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Official Registry Overview & Definition
Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system is a non-billable ICD-10-CM category code T46. A more specific billable subcode must be selected for claims submission. Includes: adverse effect of correct substance properly administered; poisoning by overdose of substance; poisoning by wrong substance given or taken in error; underdosing by (inadvertently) deliberately taking less substance than prescribed or instructed. Excludes1 (not coded here): poisoning by, adverse effect of and underdosing of metaraminol T44.4; toxic reaction to local anesthesia in pregnancy O29.3-. Excludes2 (not included here): abuse and dependence of psychoactive substances F10-F19; abuse of non-dependence-producing substances F55.-; immunodeficiency due to drugs D84.821; drug reaction and poisoning affecting newborn P00-P96; pathological drug intoxication inebriation F10-F19. Code first: , for adverse effects, the nature of the adverse effect, such as:; adverse effect NOS T88.7; aspirin gastritis K29.-; blood disorders D56-D76; contact dermatitis L23-L25; dermatitis due to substances taken internally L27.-; nephropathy N14.0-N14.2. Use additional code: code(s) to specify:; manifestations of poisoning; underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9); underdosing of medication regimen (Z91.12-, Z91.13-). 7th character: The appropriate 7th character is to be added to each code from category T46.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for T46 in the official ICD-10-CM tabular list.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) deliberately taking less substance than prescribed or instructed
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- poisoning by, adverse effect of and underdosing of metaraminol T44.4
- toxic reaction to local anesthesia in pregnancy O29.3-
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- abuse and dependence of psychoactive substances F10-F19
- abuse of non-dependence-producing substances F55.-
- immunodeficiency due to drugs D84.821
- drug reaction and poisoning affecting newborn P00-P96
- pathological drug intoxication inebriation F10-F19
Code First
Underlying conditions that must be sequenced before this code.
- , for adverse effects, the nature of the adverse effect, such as:
- adverse effect NOS T88.7
- aspirin gastritis K29.-
- blood disorders D56-D76
- contact dermatitis L23-L25
- dermatitis due to substances taken internally L27.-
- nephropathy N14.0-N14.2
Use Additional Code
Supplementary codes the tabular list directs you to add.
- code(s) to specify:
- manifestations of poisoning
- underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
- underdosing of medication regimen (Z91.12-, Z91.13-)
Frequently Asked Questions (FAQ) & Clinical Guidance
Can T46 be billed directly?
No. T46 (Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Does T46 require a 7th character?
Yes. The appropriate 7th character is to be added to each code from category T46.
What can't be coded together with T46?
Per Excludes1 instructions, T46 must not be reported with: poisoning by, adverse effect of and underdosing of metaraminol (T44.4); toxic reaction to local anesthesia in pregnancy (O29.3-).
Can T46 be reported alongside related conditions?
Per Excludes2 instructions, T46 and the following may both be reported when both are present: abuse and dependence of psychoactive substances (F10-F19); abuse of non-dependence-producing substances (F55.-); immunodeficiency due to drugs (D84.821); drug reaction and poisoning affecting newborn (P00-P96).
Does T46 need to be sequenced after another code?
Yes. Code first: , for adverse effects, the nature of the adverse effect, such as:; adverse effect NOS (T88.7); aspirin gastritis (K29.-); blood disorders (D56-D76).
Codes in This Family (40)
Official ICD-10-CM classifications in the same code family as T46, with their registry titles.
- T46.0 — Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0X — Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0X1 — Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional)
- T46.0X1A — Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), initial encounter
- T46.0X1D — Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), subsequent encounter
- T46.0X1S — Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional), sequela
- T46.0X2 — Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm
- T46.0X2A — Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, initial encounter
- T46.0X2D — Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, subsequent encounter
- T46.0X2S — Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm, sequela
- T46.0X3 — Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault
- T46.0X3A — Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault, initial encounter
- T46.0X3D — Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault, subsequent encounter
- T46.0X3S — Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault, sequela
- T46.0X4 — Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined
- T46.0X4A — Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, initial encounter
- T46.0X4D — Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, subsequent encounter
- T46.0X4S — Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined, sequela
- T46.0X5 — Adverse effect of cardiac-stimulant glycosides and drugs of similar action
- T46.0X5A — Adverse effect of cardiac-stimulant glycosides and drugs of similar action, initial encounter
- T46.0X5D — Adverse effect of cardiac-stimulant glycosides and drugs of similar action, subsequent encounter
- T46.0X5S — Adverse effect of cardiac-stimulant glycosides and drugs of similar action, sequela
- T46.0X6 — Underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0X6A — Underdosing of cardiac-stimulant glycosides and drugs of similar action, initial encounter
- T46.0X6D — Underdosing of cardiac-stimulant glycosides and drugs of similar action, subsequent encounter
- T46.0X6S — Underdosing of cardiac-stimulant glycosides and drugs of similar action, sequela
- T46.1 — Poisoning by, adverse effect of and underdosing of calcium-channel blockers
- T46.1X — Poisoning by, adverse effect of and underdosing of calcium-channel blockers
- T46.1X1 — Poisoning by calcium-channel blockers, accidental (unintentional)
- T46.1X1A — Poisoning by calcium-channel blockers, accidental (unintentional), initial encounter
- T46.1X1D — Poisoning by calcium-channel blockers, accidental (unintentional), subsequent encounter
- T46.1X1S — Poisoning by calcium-channel blockers, accidental (unintentional), sequela
- T46.1X2 — Poisoning by calcium-channel blockers, intentional self-harm
- T46.1X2A — Poisoning by calcium-channel blockers, intentional self-harm, initial encounter
- T46.1X2D — Poisoning by calcium-channel blockers, intentional self-harm, subsequent encounter
- T46.1X2S — Poisoning by calcium-channel blockers, intentional self-harm, sequela
- T46.1X3 — Poisoning by calcium-channel blockers, assault
- T46.1X3A — Poisoning by calcium-channel blockers, assault, initial encounter
- T46.1X3D — Poisoning by calcium-channel blockers, assault, subsequent encounter
- T46.1X3S — Poisoning by calcium-channel blockers, assault, sequela
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:
ICD Code T41
Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases
ICD Code T42
Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs
ICD Code T43
Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified
ICD Code T44
Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system
ICD Code T45
Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified
ICD Code T47
Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system
ICD Code T48
Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system
ICD Code T49
Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs
ICD Code T50
Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances