T88.6 is the authoritative medical code for Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered. This classification is used in medical billing and clinical recording to specify the clinical criteria for anaphylactic reaction due to adverse effect of correct drug or medicament properly administered (ICD-10-CM T88.6), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Official Registry Overview & Definition
Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered is a non-billable ICD-10-CM category code T88.6. A more specific billable subcode must be selected for claims submission. Inclusion terms: Anaphylactic shock due to adverse effect of correct drug or medicament properly administered; Anaphylactoid reaction NOS. Excludes1 (not coded here): anaphylactic reaction due to serum T80.5-; anaphylactic shock or reaction due to adverse food reaction T78.0-. Excludes2 (not included here): complication following infusion, transfusion and therapeutic injection T80.-; complication following procedure NEC T81.-; complications of anesthesia in labor and delivery O74.-; complications of anesthesia in pregnancy O29.-; complications of anesthesia in puerperium O89.-; complications of devices, implants and grafts T82-T85; complications of obstetric surgery and procedure O75.4; dermatitis due to drugs and medicaments (L23.3, L24.4, L25.1, L27.0-L27.1); poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4); specified complications classified elsewhere; any encounters with medical care for postprocedural conditions in which no complications are present, such as:; artificial opening status Z93.-; closure of external stoma Z43.-; fitting and adjustment of external prosthetic device Z44.-; burns and corrosions from local applications and irradiation T20-T32; complications of surgical procedures during pregnancy, childbirth and the puerperium O00-O9A; mechanical complication of respirator ventilator; poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6); postprocedural fever R50.82; specified complications classified elsewhere, such as:; cerebrospinal fluid leak from spinal puncture G97.0; colostomy malfunction K94.0-; disorders of fluid and electrolyte imbalance E86-E87; functional disturbances following cardiac surgery I97.0-I97.1; intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-); ostomy complications (J95.0-, K94.-, N99.5-); postgastric surgery syndromes K91.1; postlaminectomy syndrome NEC M96.1; postmastectomy lymphedema syndrome I97.2; postsurgical blind-loop syndrome K91.2; ventilator associated pneumonia J95.851. Use additional code: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). 7th character: The appropriate 7th character is to be added to each code from category T88.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for T88.6 in the official ICD-10-CM tabular list.
Inclusion Terms
Alternative terms the tabular list files under this code.
- Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
- Anaphylactoid reaction NOS
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- anaphylactic reaction due to serum T80.5-
- anaphylactic shock or reaction due to adverse food reaction T78.0-
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- complication following infusion, transfusion and therapeutic injection T80.-
- complication following procedure NEC T81.-
- complications of anesthesia in labor and delivery O74.-
- complications of anesthesia in pregnancy O29.-
- complications of anesthesia in puerperium O89.-
- complications of devices, implants and grafts T82-T85
- complications of obstetric surgery and procedure O75.4
- dermatitis due to drugs and medicaments (L23.3, L24.4, L25.1, L27.0-L27.1)
- poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)
- specified complications classified elsewhere
- any encounters with medical care for postprocedural conditions in which no complications are present, such as:
- artificial opening status Z93.-
- closure of external stoma Z43.-
- fitting and adjustment of external prosthetic device Z44.-
- burns and corrosions from local applications and irradiation T20-T32
- complications of surgical procedures during pregnancy, childbirth and the puerperium O00-O9A
- mechanical complication of respirator ventilator
- poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
- postprocedural fever R50.82
- specified complications classified elsewhere, such as:
- cerebrospinal fluid leak from spinal puncture G97.0
- colostomy malfunction K94.0-
- disorders of fluid and electrolyte imbalance E86-E87
- functional disturbances following cardiac surgery I97.0-I97.1
- intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
- ostomy complications (J95.0-, K94.-, N99.5-)
- postgastric surgery syndromes K91.1
- postlaminectomy syndrome NEC M96.1
- postmastectomy lymphedema syndrome I97.2
- postsurgical blind-loop syndrome K91.2
- ventilator associated pneumonia J95.851
Use Additional Code
Supplementary codes the tabular list directs you to add.
- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
- code(s) to identify the specified condition resulting from the complication
- code to identify devices involved and details of circumstances Y62-Y82
Frequently Asked Questions (FAQ) & Clinical Guidance
Can T88.6 be billed directly?
No. T88.6 (Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Does T88.6 require a 7th character?
Yes. The appropriate 7th character is to be added to each code from category T88.
What can't be coded together with T88.6?
Per official ICD-10-CM Excludes1 instructions, T88.6 must not be reported together with: anaphylactic reaction due to serum (T80.5-); anaphylactic shock or reaction due to adverse food reaction (T78.0-).
Can T88.6 be reported alongside related conditions?
Per official ICD-10-CM Excludes2 instructions, T88.6 and the following are not considered part of each other and may both be reported when both conditions are present: complication following infusion, transfusion and therapeutic injection (T80.-); complication following procedure NEC (T81.-); complications of anesthesia in labor and delivery (O74.-); complications of anesthesia in pregnancy (O29.-).
Is an additional code needed with T88.6?
Use additional code(s) to specify: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5); code(s) to identify the specified condition resulting from the complication; code to identify devices involved and details of circumstances (Y62-Y82).
Nearest Codes in This Family
Official ICD-10-CM classifications closest to T88.6 in its code family, with their registry titles.
- T88 — Other complications of surgical and medical care, not elsewhere classified
- T88.0 — Infection following immunization
- T88.0XXA — Infection following immunization, initial encounter
- T88.0XXD — Infection following immunization, subsequent encounter
- T88.0XXS — Infection following immunization, sequela
- T88.1 — Other complications following immunization, not elsewhere classified
- T88.1XXA — Other complications following immunization, not elsewhere classified, initial encounter
- T88.1XXD — Other complications following immunization, not elsewhere classified, subsequent encounter
- T88.1XXS — Other complications following immunization, not elsewhere classified, sequela
- T88.2 — Shock due to anesthesia
View all 40 codes in the T88 family
Indexed Clinical Terms (3)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Allergy, allergic (reaction) (to), shock (anaphylactic), due to, adverse effect of correct medicinal substance properly administered
- Shock, anaphylactic, due to drug or medicinal substance, correct substance properly administered
- Shock, drug, due to correct substance properly administered