CPT code 52352 represents a comprehensive endoscopic procedure performed by a urologist to address calculi (stones) located within the ureter or renal pelvis. The formal descriptor is Cystourethroscopy, with ureteroscopy and/or pyeloscopy; with removal or manipulation of calculus (ureteral catheterization is included). This minimally invasive intervention is an essential treatment modality for patients experiencing acute renal colic, obstructive uropathy, or persistent symptomatic stones that have not resolved with conservative medical expulsive therapy. During the procedure, the patient is typically placed in the dorsal lithotomy position under general, spinal, or deep sedation anesthesia. The physician begins by inserting a cystoscope through the urethral meatus, navigating it into the urinary bladder. This allows for direct visual inspection of the lower urinary tract and identification of the ureteral orifices. Once the target ureteral orifice is located, a guidewire is carefully advanced under fluoroscopic guidance through the orifice, up the ureter, and into the renal pelvis. Following guidewire placement, the physician introduces a ureteroscope, which may be either a semi-rigid or a flexible instrument depending on the anatomical location of the stone. The ureteroscope is advanced over the guidewire or alongside it, allowing for detailed direct visualization of the ureteral lumen and, if necessary, the inner structures of the kidney (pyeloscopy). Upon successfully locating the calculus, the urologist deploys specialized endoscopic instruments, such as a wire stone basket or mechanical grasping forceps, through the working channel of the ureteroscope. The stone is meticulously ensnared and extracted intact. In some clinical scenarios, rather than complete extraction, the stone is manipulated. For instance, it may be pushed proximally into the renal pelvis (a maneuver known as pushback) to relieve an acute obstruction or to optimally position the calculus for subsequent extracorporeal shock wave lithotripsy (ESWL). It is crucial for accurate medical coding and billing to note that CPT code 52352 applies strictly to the removal or manipulation of stones that remain whole or are removed without the need for intra-corporeal fragmentation. If the stone is too large or impacted and requires the use of laser, pneumatic, or electrohydraulic lithotripsy to be broken down before the fragments can be extracted, the appropriate code to report would be CPT 52353 instead. Furthermore, the descriptor explicitly states that standard ureteral catheterization is bundled into this code and should not be reported separately. However, if a temporary indwelling double-J ureteral stent is placed at the conclusion of the procedure to ensure proper urinary drainage and to prevent stricture or swelling, CPT code 52332 may often be reported in conjunction with 52352, subject to specific National Correct Coding Initiative (NCCI) edits and appropriate modifier usage (such as modifier 51 for multiple procedures). Comprehensive documentation of the exact procedural steps, instruments used, and the ultimate fate of the calculus is imperative to substantiate the selection of CPT 52352.