CPT code 54120 describes the surgical procedure for the partial amputation of the penis, an intervention most frequently indicated for the definitive management of localized penile malignancies. Squamous cell carcinoma constitutes the vast majority of penile cancers, and when the lesion is isolated to the distal aspect of the organ, such as the glans penis or the distal prepuce and shaft, a partial penectomy offers a balance between oncological control and functional preservation. The primary goal of this partial amputation is to completely excise the neoplastic growth with negative surgical margins, typically targeting an adequate tumor-free margin based on intraoperative frozen sections, while preserving sufficient penile length to allow the patient to direct their urinary stream while standing and potentially maintain sexual function. Beyond oncologic indications, partial amputation of the penis may also be medically necessary in cases of severe and irreversible ischemic tissue necrosis resulting from advanced microvascular disease, devastating infections such as Fournier's gangrene that have caused localized distal death of tissue, or severe traumatic avulsion or crushing injuries where reconstructive efforts are surgically impossible or have previously failed. The operative procedure requires meticulous dissection. Following the administration of general or regional anesthesia, the surgeon typically applies a tourniquet at the base of the penis to maintain a bloodless surgical field. A circumferential skin incision is meticulously made proximal to the targeted diseased tissue. The surgeon identifies, ligates, and divides the deep and superficial dorsal venous complexes and associated neurovascular structures. The corpora cavernosa, which are the primary erectile bodies, are sharply transected, and their dense fibrous outer layer, the tunica albuginea, is securely closed using heavy absorbable sutures to prevent postoperative hemorrhage and preserve the integrity of the remaining erectile tissue. The corpus spongiosum, which houses the urethra, is preserved slightly longer than the corpora cavernosa. The distal urethra is then spatulated, meaning it is slit longitudinally, and meticulously sutured to the adjacent penile skin to fashion a neo-meatus. This crucial step prevents urethral stricture and maintains patency for normal micturition. A urethral catheter is temporarily left in place to divert urine away from the healing surgical margins. Postoperative care involves careful monitoring for hematoma formation, infection, and ensuring proper psychological support due to the profound impact of the surgery on body image and sexual function.