C49.1 is the authoritative medical code for Malignant neoplasm of connective and soft tissue of upper limb, including shoulder. This classification is used in medical billing and clinical recording to specify the clinical criteria for malignant neoplasm of connective and soft tissue of upper limb, including shoulder (ICD-10-CM C49.1), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Official Registry Overview & Definition
Malignant neoplasm of connective and soft tissue of upper limb, including shoulder is a non-billable ICD-10-CM category code C49.1. A more specific billable subcode must be selected for claims submission. Includes: malignant neoplasm of blood vessel; malignant neoplasm of bursa; malignant neoplasm of cartilage; malignant neoplasm of fascia; malignant neoplasm of fat; malignant neoplasm of ligament, except uterine; malignant neoplasm of lymphatic vessel; malignant neoplasm of muscle; malignant neoplasm of synovia; malignant neoplasm of tendon sheath. Excludes1 (not coded here): malignant neoplasm of cartilage (of):; articular C40-C41; larynx C32.3; nose C30.0; malignant neoplasm of connective tissue of breast C50.-. Excludes2 (not included here): Kaposi's sarcoma of soft tissue C46.1; malignant neoplasm of heart C38.0; malignant neoplasm of peripheral nerves and autonomic nervous system C47.-; malignant neoplasm of peritoneum C48.2; malignant neoplasm of retroperitoneum C48.0; malignant neoplasm of uterine ligament C57.3; mesothelioma C45.-.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for C49.1 in the official ICD-10-CM tabular list.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon sheath
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- malignant neoplasm of cartilage (of):
- articular C40-C41
- larynx C32.3
- nose C30.0
- malignant neoplasm of connective tissue of breast C50.-
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- Kaposi's sarcoma of soft tissue C46.1
- malignant neoplasm of heart C38.0
- malignant neoplasm of peripheral nerves and autonomic nervous system C47.-
- malignant neoplasm of peritoneum C48.2
- malignant neoplasm of retroperitoneum C48.0
- malignant neoplasm of uterine ligament C57.3
- mesothelioma C45.-
Frequently Asked Questions (FAQ) & Clinical Guidance
Can C49.1 be billed directly?
No. C49.1 (Malignant neoplasm of connective and soft tissue of upper limb, including shoulder) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
What can't be coded together with C49.1?
Per official ICD-10-CM Excludes1 instructions, C49.1 must not be reported together with: malignant neoplasm of cartilage (of):; articular (C40-C41); larynx (C32.3); nose (C30.0).
Can C49.1 be reported alongside related conditions?
Per official ICD-10-CM Excludes2 instructions, C49.1 and the following are not considered part of each other and may both be reported when both conditions are present: Kaposi's sarcoma of soft tissue (C46.1); malignant neoplasm of heart (C38.0); malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-); malignant neoplasm of peritoneum (C48.2).
Nearest Codes in This Family
Official ICD-10-CM classifications closest to C49.1 in its code family, with their registry titles.
- C49 — Malignant neoplasm of other connective and soft tissue
- C49.0 — Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.10 — Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
- C49.11 — Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
- C49.12 — Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
- C49.2 — Malignant neoplasm of connective and soft tissue of lower limb, including hip
- C49.20 — Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
- C49.21 — Malignant neoplasm of connective and soft tissue of right lower limb, including hip
- C49.22 — Malignant neoplasm of connective and soft tissue of left lower limb, including hip
- C49.3 — Malignant neoplasm of connective and soft tissue of thorax
View all 23 codes in the C49 family
Neoplasm Table Sites (13)
Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.
- Neoplasm, neoplastic, aponeurosis, palmar — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, antecubital fossa or space — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, arm — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, elbow — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, extremity, upper — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, finger — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, forearm — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, hand — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, limb NEC, upper — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, shoulder — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, thumb — Malignant, Primary
- Neoplasm, neoplastic, connective tissue NEC, wrist — Malignant, Primary
- Neoplasm, neoplastic, fascia, palmar — Malignant, Primary