Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

MS-DRG 542 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH MCC (MDC 08)
MS-DRG 543 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH CC (MDC 08)
MS-DRG 544 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITHOUT CC/MCC (MDC 08)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

HCC 21 — Lymphoma and Other Cancers (supersedes HCC 22, HCC 23)

Other models: CMS-HCC V22 HCC 10 · RxHCC V08 HCC 22

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Official Registry Overview & Definition

Malignant neoplasm of connective and soft tissue of thorax is a billable ICD-10-CM diagnosis code (C49.3).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C49.3 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

malignant neoplasm of blood vessel
malignant neoplasm of bursa
malignant neoplasm of cartilage
malignant neoplasm of fascia
malignant neoplasm of fat
malignant neoplasm of ligament, except uterine
malignant neoplasm of lymphatic vessel
malignant neoplasm of muscle
malignant neoplasm of synovia
malignant neoplasm of tendon (sheath)

Inclusion Terms

Alternative terms the tabular list files under this code.

Malignant neoplasm of axilla
Malignant neoplasm of diaphragm
Malignant neoplasm of great vessels

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

malignant neoplasm of breast (C50.-) Compare C49.3 vs C50 →
malignant neoplasm of heart (C38.0) Compare C49.3 vs C38.0 →
malignant neoplasm of mediastinum (C38.1-C38.3) Compare C49.3 vs C38.1 →
malignant neoplasm of thymus (C37) Compare C49.3 vs C37 →
malignant neoplasm of cartilage (of):
articular (C40-C41) Compare C49.3 vs C40 →
larynx (C32.3) Compare C49.3 vs C32.3 →
nose (C30.0) Compare C49.3 vs C30.0 →
malignant neoplasm of connective tissue of breast (C50.-) Compare C49.3 vs C50 →

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Kaposi's sarcoma of soft tissue (C46.1) Compare C49.3 vs C46.1 →
malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-) Compare C49.3 vs C47 →
malignant neoplasm of peritoneum (C48.2) Compare C49.3 vs C48.2 →
malignant neoplasm of retroperitoneum (C48.0) Compare C49.3 vs C48.0 →
malignant neoplasm of uterine ligament (C57.3) Compare C49.3 vs C57.3 →
mesothelioma (C45.-) Compare C49.3 vs C45 →

Neoplasm Table Sites (14)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

Neoplasm, neoplastic, aorta (thoracic) — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, axilla — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, chest (wall) — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, diaphragm — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, great vessels NEC — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, infraclavicular region — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, intrathoracic — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, scapular region — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, thoracic (duct) (wall) — Malignant, Primary
Neoplasm, neoplastic, connective tissue NEC, thorax — Malignant, Primary
Neoplasm, neoplastic, diaphragm — Malignant, Primary
Neoplasm, neoplastic, great vessels NEC — Malignant, Primary
Neoplasm, neoplastic, thorax, thoracic (cavity) (organs NEC), duct — Malignant, Primary
Neoplasm, neoplastic, vena cava (abdominal) (inferior), superior — Malignant, Primary

Frequently Compared Codes

The official Excludes notes on C49.3 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

No changes recorded for this code — unchanged since the FY2016 baseline of the change ledger.

Verify Before Coding

CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Official ICD-10-CM tabular notes on other codes that name C49.3 or its code family.

4 Excludes1 notes: C38.0, C40 (via C49.-), C40-C41 (via C49.-), C41 (via C49.-).

1 Code First instructions: M63 (via C49.-).

Potential MS-DRG Relationships (FY2026)

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 2 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 542 (MDC 08), DRG 543 (MDC 08), DRG 544 (MDC 08).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO024 — Sarcoma (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Contextual Map

Every relationship of C49.3 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

C00-D49 — Chapter 2: Neoplasms (C00-D49) (C00-D49) [Hierarchy]
C00-C75 — Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue [Hierarchy]

Excludes1

C37 — Malignant neoplasm of thymus [Excludes1]: “malignant neoplasm of thymus (C37)” · check together
C38.0 — Malignant neoplasm of heart [Excludes1]: “malignant neoplasm of heart (C38.0)” · check together
C38.1 — Malignant neoplasm of anterior mediastinum [Excludes1]: “malignant neoplasm of mediastinum (C38.1-C38.3)” · check together
C38.3 — Malignant neoplasm of mediastinum, part unspecified [Excludes1]: “malignant neoplasm of mediastinum (C38.1-C38.3)” · check together
C50 — Malignant neoplasm of breast [Excludes1]: “malignant neoplasm of breast (C50.-)” · check together

Referenced by Excludes1 notes

C38.0 — Malignant neoplasm of heart [Excludes1]: “malignant neoplasm of great vessels (C49.3)” · check together
C40 — Malignant neoplasm of bone and articular cartilage of limbs [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together
C40-C41 — Malignant neoplasms of bone and articular cartilage (C40-C41) [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together
C41 — Malignant neoplasm of bone and articular cartilage of other and unspecified sites [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together

Referenced by Code First instructions

M63 — Disorders of muscle in diseases classified elsewhere [Code First](via C49.-): “neoplasm (C49.-, C79.89, D21.-, D48.1-)” · check together

Clinical classification (CCSR)

NEO024 — Sarcoma [CCSR]

Risk adjustment (CMS-HCC)

HCC 21 — Lymphoma and Other Cancers [CMS-HCC]: “Lymphoma and Other Cancers — supersedes HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors)”

Potential MS-DRG

CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”
DRG 542 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH MCC [MS-DRG]: “PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH MCC (MDC 08)”
DRG 543 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH CC [MS-DRG]: “PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITH CC (MDC 08)”
DRG 544 — PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITHOUT CC/MCC [MS-DRG]: “PATHOLOGICAL FRACTURES AND MUSCULOSKELETAL AND CONNECTIVE TISSUE MALIGNANCY WITHOUT CC/MCC (MDC 08)”

MDC crossing · procedures (18508)

MDC 08 — Diseases and Disorders of the Musculoskeletal System and Connective Tissue [MDC crossing]: “Diseases and Disorders of the Musculoskeletal System and Connective Tissue — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
005T0ZZ — Destruction of Spinal Meninges, Open Approach [Same-MDC procedure]: “Destruction of Spinal Meninges, Open Approach — grouped in MDC 08, the procedure side of this code's crossing.” · check together
005T3ZZ — Destruction of Spinal Meninges, Percutaneous Approach [Same-MDC procedure]: “Destruction of Spinal Meninges, Percutaneous Approach — grouped in MDC 08, the procedure side of this code's crossing.” · check together
005T4ZZ — Destruction of Spinal Meninges, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Destruction of Spinal Meninges, Percutaneous Endoscopic Approach — grouped in MDC 08, the procedure side of this code's crossing.” · check together
005W0Z3 — Destruction of Cervical Spinal Cord using Laser Interstitial Thermal Therapy, Open Approach [Same-MDC procedure]: “Destruction of Cervical Spinal Cord using Laser Interstitial Thermal Therapy, Open Approach — grouped in MDC 08, the procedure side of this code's crossing.” · check together
005W0ZZ — Destruction of Cervical Spinal Cord, Open Approach [Same-MDC procedure]: “Destruction of Cervical Spinal Cord, Open Approach — grouped in MDC 08, the procedure side of this code's crossing.” · check together
and 18503 more

Neoplasm sites (14)

Neoplasm, neoplastic, aorta (thoracic) — Neoplasm, neoplastic, aorta (thoracic) — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, aorta (thoracic) (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, axilla — Neoplasm, neoplastic, connective tissue NEC, axilla — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, axilla (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, chest (wall) — Neoplasm, neoplastic, connective tissue NEC, chest (wall) — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, chest (wall) (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, diaphragm — Neoplasm, neoplastic, connective tissue NEC, diaphragm — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, diaphragm (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, great vessels NEC — Neoplasm, neoplastic, connective tissue NEC, great vessels NEC — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, great vessels NEC (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, infraclavicular region — Neoplasm, neoplastic, connective tissue NEC, infraclavicular region — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, infraclavicular region (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, intrathoracic — Neoplasm, neoplastic, connective tissue NEC, intrathoracic — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, intrathoracic (Malignant, Primary)”
Neoplasm, neoplastic, connective tissue NEC, scapular region — Neoplasm, neoplastic, connective tissue NEC, scapular region — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, connective tissue NEC, scapular region (Malignant, Primary)”
and 6 more

Nearest codes (23)

C49 — Malignant neoplasm of other connective and soft tissue [Sibling]
C49.0 — Malignant neoplasm of connective and soft tissue of head, face and neck [Sibling]
C49.1 — Malignant neoplasm of connective and soft tissue of upper limb, including shoulder [Sibling]
C49.10 — Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder [Sibling]
C49.11 — Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder [Sibling]
C49.12 — Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder [Sibling]
C49.2 — Malignant neoplasm of connective and soft tissue of lower limb, including hip [Sibling]
C49.20 — Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip [Sibling]
and 15 more

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C49.3 in its code family, with their registry titles.

C49.12 — Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
C49.2 — Malignant neoplasm of connective and soft tissue of lower limb, including hip
C49.20 — Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
C49.21 — Malignant neoplasm of connective and soft tissue of right lower limb, including hip
C49.22 — Malignant neoplasm of connective and soft tissue of left lower limb, including hip
C49.4 — Malignant neoplasm of connective and soft tissue of abdomen
C49.5 — Malignant neoplasm of connective and soft tissue of pelvis
C49.6 — Malignant neoplasm of connective and soft tissue of trunk, unspecified
C49.8 — Malignant neoplasm of overlapping sites of connective and soft tissue
C49.9 — Malignant neoplasm of connective and soft tissue, unspecified

View all codes in the C49 family

C49.3 ICD-10-CM Code: Malignant neoplasm of connective and soft tissue of thorax