C45 vs C49.3
C45 (Mesothelioma) compared with C49.3 (Malignant neoplasm of connective and soft tissue of thorax), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).
Can these codes be reported together?
Yes, when both are documented. C49.3 carries an Excludes2 note covering C45: “mesothelioma (C45.-)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
Side by side
| C45Mesothelioma | C49.3Malignant neoplasm of connective and soft tissue of thorax | |
|---|---|---|
| Billing status | Non-billable header | Billable |
| Classification | C00-D49 — Neoplasms (C00-D49) | C00-D49 — Neoplasms (C00-D49) |
| Definition | Mesothelioma is a non-billable ICD-10-CM category code (C45). | Malignant neoplasm of connective and soft tissue of thorax is a billable ICD-10-CM diagnosis code (C49.3). |
| Includes | — | malignant neoplasm of blood vessel malignant neoplasm of bursa malignant neoplasm of cartilage malignant neoplasm of fascia |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources