D48.5 ICD-10 Code: Neoplasm of uncertain behavior of… (2026)

D48.5 is the authoritative medical code for Neoplasm of uncertain behavior of skin. This classification is used in medical billing and clinical recording to specify the clinical criteria for neoplasm of uncertain behavior of skin (ICD-10-CM D48.5), ensuring healthcare documentation aligns with 2026 federal coding standards.

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Official Registry Overview & Definition

Neoplasm of uncertain behavior of skin is a billable ICD-10-CM diagnosis code D48.5. Inclusion terms: Neoplasm of uncertain behavior of anal margin; Neoplasm of uncertain behavior of anal skin; Neoplasm of uncertain behavior of perianal skin; Neoplasm of uncertain behavior of skin of breast. Excludes1 (not coded here): neoplasm of uncertain behavior of anus NOS D37.8; neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8); neoplasm of uncertain behavior of vermilion border of lip D37.0; neurofibromatosis nonmalignant Q85.0-; neoplasms of unspecified behavior D49.-.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D48.5 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

Neoplasm of uncertain behavior of anal margin
Neoplasm of uncertain behavior of anal skin
Neoplasm of uncertain behavior of perianal skin
Neoplasm of uncertain behavior of skin of breast

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

neoplasm of uncertain behavior of anus NOS D37.8
neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8)
neoplasm of uncertain behavior of vermilion border of lip D37.0
neurofibromatosis nonmalignant Q85.0-
neoplasms of unspecified behavior D49.-

Frequently Asked Questions (FAQ) & Clinical Guidance

What can't be coded together with D48.5?

Per Excludes1 instructions, D48.5 must not be reported with: neoplasm of uncertain behavior of anus NOS (D37.8); neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8); neoplasm of uncertain behavior of vermilion border of lip (D37.0); neurofibromatosis (nonmalignant) (Q85.0-).

What conditions are included under D48.5?

Neoplasm of uncertain behavior of skin includes: Neoplasm of uncertain behavior of anal margin; Neoplasm of uncertain behavior of anal skin; Neoplasm of uncertain behavior of perianal skin; Neoplasm of uncertain behavior of skin of breast.

Codes in This Family (24)

Official ICD-10-CM classifications in the same code family as D48.5, with their registry titles.

D48 — Neoplasm of uncertain behavior of other and unspecified sites
D48.0 — Neoplasm of uncertain behavior of bone and articular cartilage
D48.1 — Neoplasm of uncertain behavior of connective and other soft tissue
D48.11 — Desmoid tumor
D48.110 — Desmoid tumor of head and neck
D48.111 — Desmoid tumor of chest wall
D48.112 — Desmoid tumor, intrathoracic
D48.113 — Desmoid tumor of abdominal wall
D48.114 — Desmoid tumor, intraabdominal
D48.115 — Desmoid tumor of upper extremity and shoulder girdle
D48.116 — Desmoid tumor of lower extremity and pelvic girdle
D48.117 — Desmoid tumor of back
D48.118 — Desmoid tumor of other site
D48.119 — Desmoid tumor of unspecified site
D48.19 — Other specified neoplasm of uncertain behavior of connective and other soft tissue
D48.2 — Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
D48.3 — Neoplasm of uncertain behavior of retroperitoneum
D48.4 — Neoplasm of uncertain behavior of peritoneum
D48.6 — Neoplasm of uncertain behavior of breast
D48.60 — Neoplasm of uncertain behavior of unspecified breast
D48.61 — Neoplasm of uncertain behavior of right breast
D48.62 — Neoplasm of uncertain behavior of left breast
D48.7 — Neoplasm of uncertain behavior of other specified sites
D48.9 — Neoplasm of uncertain behavior, unspecified

Indexed Clinical Terms (3)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

Nevus, bathing trunk
Nevus, pigmented, giant
Tumor, basal cell

Neoplasm Table Sites (134)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

Neoplasm, neoplastic, abdomen, abdominal, wall — Uncertain Behavior
Neoplasm, neoplastic, ala nasi (external) — Uncertain Behavior
Neoplasm, neoplastic, anus, anal, margin — Uncertain Behavior
Neoplasm, neoplastic, anus, anal, skin — Uncertain Behavior
Neoplasm, neoplastic, auditory, canal (external) (skin) — Uncertain Behavior
Neoplasm, neoplastic, auricle, ear — Uncertain Behavior
Neoplasm, neoplastic, auricular canal (external) — Uncertain Behavior
Neoplasm, neoplastic, axilla, axillary, fold — Uncertain Behavior
Neoplasm, neoplastic, breast (connective tissue) (glandular tissue) (soft parts), skin — Uncertain Behavior
Neoplasm, neoplastic, brow — Uncertain Behavior
Neoplasm, neoplastic, canal, auditory (external) — Uncertain Behavior
Neoplasm, neoplastic, canal, auricular (external) — Uncertain Behavior
Neoplasm, neoplastic, canthus (eye) (inner) (outer) — Uncertain Behavior
Neoplasm, neoplastic, cheek, external — Uncertain Behavior
Neoplasm, neoplastic, chin — Uncertain Behavior
Neoplasm, neoplastic, columnella — Uncertain Behavior
Neoplasm, neoplastic, concha — Uncertain Behavior
Neoplasm, neoplastic, connective tissue NEC, skin NEC (dermis) — Uncertain Behavior
Neoplasm, neoplastic, ear (external) — Uncertain Behavior
Neoplasm, neoplastic, ear (external), auricle or auris — Uncertain Behavior
Neoplasm, neoplastic, ear (external), canal, external — Uncertain Behavior
Neoplasm, neoplastic, ear (external), external meatus — Uncertain Behavior
Neoplasm, neoplastic, ear (external), lobule — Uncertain Behavior
Neoplasm, neoplastic, ear (external), skin — Uncertain Behavior
Neoplasm, neoplastic, earlobe — Uncertain Behavior
Neoplasm, neoplastic, external, meatus (ear) — Uncertain Behavior
Neoplasm, neoplastic, eyebrow — Uncertain Behavior
Neoplasm, neoplastic, forehead (skin) — Uncertain Behavior
Neoplasm, neoplastic, helix — Uncertain Behavior
Neoplasm, neoplastic, jaw, skin — Uncertain Behavior
Neoplasm, neoplastic, lid (lower) (upper) — Uncertain Behavior
Neoplasm, neoplastic, lip, skin (commissure) (lower) (upper) — Uncertain Behavior
Neoplasm, neoplastic, meatus external (ear) — Uncertain Behavior
Neoplasm, neoplastic, meibomian gland — Uncertain Behavior
Neoplasm, neoplastic, nail — Uncertain Behavior
Neoplasm, neoplastic, nail, finger — Uncertain Behavior
Neoplasm, neoplastic, nail, toe — Uncertain Behavior
Neoplasm, neoplastic, nasolabial groove — Uncertain Behavior
Neoplasm, neoplastic, nates — Uncertain Behavior
Neoplasm, neoplastic, nose, nasal, ala (external) (nasi) — Uncertain Behavior
Neoplasm, neoplastic, nose, nasal, external (skin) — Uncertain Behavior
Neoplasm, neoplastic, nose, nasal, skin — Uncertain Behavior
Neoplasm, neoplastic, palpebra — Uncertain Behavior
Neoplasm, neoplastic, perianal (skin) — Uncertain Behavior
Neoplasm, neoplastic, pinna NEC (ear) — Uncertain Behavior
Neoplasm, neoplastic, scalp — Uncertain Behavior
Neoplasm, neoplastic, scar NEC — Uncertain Behavior
Neoplasm, neoplastic, skin NOS — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, abdominal wall — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, ala nasi — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, ankle — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, antecubital space — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, anus — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, arm — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, auditory canal (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, auricle (ear) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, auricular canal (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, axilla, axillary fold — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, back — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, breast — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, brow — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, buttock — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, calf — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, canthus (eye) (inner) (outer) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, cervical region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, cheek (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, chest (wall) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, chin — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, clavicular area — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, columnella — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, concha — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, ear (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, elbow — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, eyebrow — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, eyelid — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, face NOS — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, finger — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, flank — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, foot — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, forearm — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, forehead — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, glabella — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, gluteal region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, groin — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, hand — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, head NEC — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, heel — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, helix — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, hip — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, infraclavicular region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, inguinal region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, jaw — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, knee — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, leg — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, lid (lower) (upper) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, limb NEC — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, limb NEC, lower — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, limb NEC, upper — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, lip (lower) (upper) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, meatus, acoustic (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, nates — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, neck — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, nose (external) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, palm — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, palpebra — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, perianal — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, perineum — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, pinna — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, plantar — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, popliteal fossa or space — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, pubes — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, sacrococcygeal region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, scalp — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, scapular region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, shoulder — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, sole (foot) — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, specified sites NEC — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, submammary fold — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, supraclavicular region — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, temple — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, thigh — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, thoracic wall — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, thumb — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, toe — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, tragus — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, trunk — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, umbilicus — Uncertain Behavior
Neoplasm, neoplastic, skin NOS, wrist — Uncertain Behavior
Neoplasm, neoplastic, sudoriferous, sudoriparous gland, site unspecified — Uncertain Behavior
Neoplasm, neoplastic, sweat gland, site unspecified (apocrine) (eccrine) — Uncertain Behavior
Neoplasm, neoplastic, temple (skin) — Uncertain Behavior
Neoplasm, neoplastic, temporal, region, skin — Uncertain Behavior
Neoplasm, neoplastic, tragus — Uncertain Behavior
Neoplasm, neoplastic, umbilicus, umbilical — Uncertain Behavior

Related Codes & Numerical Sequence (Crawl Map)

Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:

ICD Code D43.5 Code

ICD Code D44.5 Neoplasm of uncertain behavior of pineal gland

ICD Code D45.5 Code

ICD Code D46.5 Code

ICD Code D47.5 Code

ICD Code D49.5 Neoplasm of unspecified behavior of other genitourinary organs