ICD-10/D56.5

D56.5 ICD 2026 Code: Hemoglobin E-beta thalassemia

D56.5 is the authoritative medical code for Hemoglobin E-beta thalassemia. This classification is used in medical billing and clinical recording to specify the clinical criteria for hemoglobin e-beta thalassemia (ICD-10-CM D56.5), ensuring healthcare documentation aligns with 2026 federal coding standards.

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Official Registry Overview & Definition

Hemoglobin E-beta thalassemia is a billable ICD-10-CM diagnosis code D56.5. Excludes1 (not coded here): beta thalassemia D56.1; beta thalassemia minor D56.3; beta thalassemia trait D56.3; delta-beta thalassemia D56.2; delta-beta thalassemia trait D56.3; hemoglobin E disease D58.2; other hemoglobinopathies D58.2; sickle-cell beta thalassemia D57.4-; sickle-cell thalassemia D57.4-.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D56.5 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • beta thalassemia D56.1
  • beta thalassemia minor D56.3
  • beta thalassemia trait D56.3
  • delta-beta thalassemia D56.2
  • delta-beta thalassemia trait D56.3
  • hemoglobin E disease D58.2
  • other hemoglobinopathies D58.2
  • sickle-cell beta thalassemia D57.4-
  • sickle-cell thalassemia D57.4-

Frequently Asked Questions (FAQ) & Clinical Guidance

What can't be coded together with D56.5?

Per Excludes1 instructions, D56.5 must not be reported with: beta thalassemia (D56.1); beta thalassemia minor (D56.3); beta thalassemia trait (D56.3); delta-beta thalassemia (D56.2).

Codes in This Family (8)

Official ICD-10-CM classifications in the same code family as D56.5, with their registry titles.

  • D56 — Thalassemia
  • D56.0 — Alpha thalassemia
  • D56.1 — Beta thalassemia
  • D56.2 — Delta-beta thalassemia
  • D56.3 — Thalassemia minor
  • D56.4 — Hereditary persistence of fetal hemoglobin [HPFH]
  • D56.8 — Other thalassemias
  • D56.9 — Thalassemia, unspecified

Indexed Clinical Terms (3)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Disease, diseased, hemoglobin or Hb, E-beta thalassemia
  • Hemoglobin, E-beta thalassemia
  • Thalassemia (anemia) (disease), hemoglobin, E-beta

Related Codes & Numerical Sequence (Crawl Map)

Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:

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