ICD-10/E88.0

E88.0 ICD 2026 Code: Disorders of plasma-protein metabolism, not elsewhere classified

E88.0 is the authoritative medical code for Disorders of plasma-protein metabolism, not elsewhere classified. This classification is used in medical billing and clinical recording to specify the clinical criteria for disorders of plasma-protein metabolism, not elsewhere classified (ICD-10-CM E88.0), ensuring healthcare documentation aligns with 2026 federal coding standards.

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Official Registry Overview & Definition

Disorders of plasma-protein metabolism, not elsewhere classified is a non-billable ICD-10-CM category code E88.0. A more specific billable subcode must be selected for claims submission. Excludes1 (not coded here): monoclonal gammopathy (of undetermined significance) D47.2; polyclonal hypergammaglobulinemia D89.0; Waldenström macroglobulinemia C88.00; histiocytosis X chronic C96.6; androgen insensitivity syndrome E34.5-; congenital adrenal hyperplasia E25.0; hemolytic anemias attributable to enzyme disorders D55.-; Marfan syndrome Q87.4-; 5-alpha-reductase deficiency E29.1. Excludes2 (not included here): disorder of lipoprotein metabolism E78.-; Ehlers-Danlos syndromes Q79.6-. Use additional code: codes for associated conditions.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for E88.0 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • monoclonal gammopathy (of undetermined significance) D47.2
  • polyclonal hypergammaglobulinemia D89.0
  • Waldenström macroglobulinemia C88.00
  • histiocytosis X chronic C96.6
  • androgen insensitivity syndrome E34.5-
  • congenital adrenal hyperplasia E25.0
  • hemolytic anemias attributable to enzyme disorders D55.-
  • Marfan syndrome Q87.4-
  • 5-alpha-reductase deficiency E29.1

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • disorder of lipoprotein metabolism E78.-
  • Ehlers-Danlos syndromes Q79.6-

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • codes for associated conditions

Frequently Asked Questions (FAQ) & Clinical Guidance

Can E88.0 be billed directly?

No. E88.0 (Disorders of plasma-protein metabolism, not elsewhere classified) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

What can't be coded together with E88.0?

Per Excludes1 instructions, E88.0 must not be reported with: monoclonal gammopathy (of undetermined significance) (D47.2); polyclonal hypergammaglobulinemia (D89.0); Waldenström macroglobulinemia (C88.00); histiocytosis X (chronic) (C96.6).

Can E88.0 be reported alongside related conditions?

Per Excludes2 instructions, E88.0 and the following may both be reported when both are present: disorder of lipoprotein metabolism (E78.-); Ehlers-Danlos syndromes (Q79.6-).

Is an additional code needed with E88.0?

Use additional code(s) to specify: codes for associated conditions.

Codes in This Family (3)

Official ICD-10-CM classifications in the same code family as E88.0, with their registry titles.

  • E88.01 — Alpha-1-antitrypsin deficiency
  • E88.02 — Plasminogen deficiency
  • E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified

Related Codes & Numerical Sequence (Crawl Map)

Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures:

ICD Code E83.0 Disorders of copper metabolism
ICD Code E84.0 Cystic fibrosis with pulmonary manifestations
ICD Code E85.0 Non-neuropathic heredofamilial amyloidosis
ICD Code E86.0 Dehydration
ICD Code E87.0 Hyperosmolality and hypernatremia
ICD Code E89.0 Postprocedural hypothyroidism
ICD Code E90.0 ICD-10 Clinical Diagnosis (E90.0)
ICD Code E91.0 ICD-10 Clinical Diagnosis (E91.0)
ICD Code E92.0 ICD-10 Clinical Diagnosis (E92.0)
ICD Code E93.0 ICD-10 Clinical Diagnosis (E93.0)
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