Skip to main content
ICD-10/G92.03

G92.03 ICD-10-CM Code: Immune effector cell-associated neurotoxicity syndrome, grade 3

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 023 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR (MDC 01)
  • MS-DRG 024 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC (MDC 01)
  • MS-DRG 091 — OTHER DISORDERS OF NERVOUS SYSTEM WITH MCC (MDC 01)
  • MS-DRG 092 — OTHER DISORDERS OF NERVOUS SYSTEM WITH CC (MDC 01)
  • MS-DRG 093 — OTHER DISORDERS OF NERVOUS SYSTEM WITHOUT CC/MCC (MDC 01)
  • MS-DRG 791 — PREMATURITY WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Immune effector cell-associated neurotoxicity syndrome, grade 3 is a billable ICD-10-CM diagnosis code (G92.03).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for G92.03 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • ICANS, grade 3

Code First

Underlying conditions that must be sequenced before this code.

  • underlying cause such as:
  • complications of immune effector cellular therapy (T80.82)

Code Also

Additional codes that may be required to fully describe the encounter.

  • Code also, if applicable, associated signs and symptoms, such as:
  • cerebral edema (G93.6)
  • unspecified convulsions (R56.9)

Change history

  • FY2022 — 2021-10-01
    Added to the code set
    Immune effector cell-associated neurotoxicity syndrome, grade 3
    FY2022 changes

Verify Before Coding

  • Billable — reportable as written.
  • Principal-diagnosis restriction. The Medicare Code Editor lists this code as unacceptable as a principal diagnosis: it describes a circumstance influencing health status rather than a current illness or injury being treated. It is valid as a secondary diagnosis.
  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Contextual Map

Every relationship of G92.03 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • G92.0 — Immune effector cell-associated neurotoxicity syndrome [Hierarchy]

Referenced by Use Additional Code instructions

  • G90.81 — Serotonin syndrome [Use Additional Code](via G92.-): “toxic encephalopathy (G92.-)”
  • T80.82 — Complication of immune effector cellular therapy [Use Additional Code](via G92.0.-): “immune effector cell-associated neurotoxicity syndrome (G92.0-)”

Clinical classification (CCSR)

  • NVS020 — Other nervous system disorders (neither hereditary nor degenerative) [CCSR]
  • INJ030 — Drug induced or toxic related condition [CCSR]

Potential MS-DRG

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”
  • DRG 023 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR [MS-DRG]: “CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR (MDC 01)”
  • DRG 024 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC [MS-DRG]: “CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC (MDC 01)”
  • DRG 091 — OTHER DISORDERS OF NERVOUS SYSTEM WITH MCC [MS-DRG]: “OTHER DISORDERS OF NERVOUS SYSTEM WITH MCC (MDC 01)”
  • DRG 092 — OTHER DISORDERS OF NERVOUS SYSTEM WITH CC [MS-DRG]: “OTHER DISORDERS OF NERVOUS SYSTEM WITH CC (MDC 01)”
  • DRG 093 — OTHER DISORDERS OF NERVOUS SYSTEM WITHOUT CC/MCC [MS-DRG]: “OTHER DISORDERS OF NERVOUS SYSTEM WITHOUT CC/MCC (MDC 01)”
  • DRG 791 — PREMATURITY WITH MAJOR PROBLEMS [MS-DRG]: “PREMATURITY WITH MAJOR PROBLEMS (MDC 15)”
  • DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS [MS-DRG]: “FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)”

Nearest codes (9)

  • G92 — Toxic encephalopathy [Sibling]
  • G92.0 — Immune effector cell-associated neurotoxicity syndrome [Sibling]
  • G92.00 — Immune effector cell-associated neurotoxicity syndrome, grade unspecified [Sibling]
  • G92.01 — Immune effector cell-associated neurotoxicity syndrome, grade 1 [Sibling]
  • G92.02 — Immune effector cell-associated neurotoxicity syndrome, grade 2 [Sibling]
  • G92.04 — Immune effector cell-associated neurotoxicity syndrome, grade 4 [Sibling]
  • G92.05 — Immune effector cell-associated neurotoxicity syndrome, grade 5 [Sibling]
  • G92.8 — Other toxic encephalopathy [Sibling]
  • and 1 more

Change history

  • FY2022 — Added to the code set [Change history]

Referenced by Other Codes

Clinical classification (AHRQ CCSR):NVS020 — Other nervous system disorders (neither hereditary nor degenerative) (default); INJ030 — Drug induced or toxic related condition.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 52 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 7 MS-DRGs: DRG 023 (MDC 01), DRG 024 (MDC 01), DRG 091 (MDC 01), DRG 092 (MDC 01), DRG 093 (MDC 01), DRG 791 (MDC 15), DRG 793 (MDC 15).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name G92.03 or its code family.

2 Use Additional Code instructions across 2 chapters: G90.81 (via G92.-), T80.82 (via G92.0.-).

Nearest Codes in This Family

Official ICD-10-CM classifications closest to G92.03 in its code family, with their registry titles.

  • G92 — Toxic encephalopathy
  • G92.0 — Immune effector cell-associated neurotoxicity syndrome
  • G92.00 — Immune effector cell-associated neurotoxicity syndrome, grade unspecified
  • G92.01 — Immune effector cell-associated neurotoxicity syndrome, grade 1
  • G92.02 — Immune effector cell-associated neurotoxicity syndrome, grade 2
  • G92.04 — Immune effector cell-associated neurotoxicity syndrome, grade 4
  • G92.05 — Immune effector cell-associated neurotoxicity syndrome, grade 5
  • G92.8 — Other toxic encephalopathy
  • G92.9 — Unspecified toxic encephalopathy

View all codes in the G92 family