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K52.22 ICD-10-CM Code: Food protein-induced enteropathy

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 391 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC (MDC 06)
  • MS-DRG 392 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC (MDC 06)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Food protein-induced enteropathy is a billable ICD-10-CM diagnosis code (K52.22).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for K52.22 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • noninfective inflammatory bowel disease

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify type of food allergy (Z91.01-, Z91.02-)

Indexed Clinical Terms (4)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Allergy, allergic (reaction) (to), milk protein, enteropathy
  • Enteritis (acute) (diarrheal) (hemorrhagic) (noninfective), allergic, with, food protein-induced enteropathy
  • Enteropathy, food protein-induced
  • Gastroenteritis (acute) (chronic) (noninfectious), allergic, with, food protein-induced enteropathy

Frequently Compared Codes

The official Excludes notes on K52.22 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2017 — 2016-10-01
    Added to the code set
    Food protein-induced enteropathy
    FY2017 changes

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Official ICD-10-CM tabular notes on other codes that name K52.22 or its code family.

3 Excludes1 notes: T61, T62, T78.4.

1 Excludes2 notes: T78.1.

Potential MS-DRG Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 391 (MDC 06), DRG 392 (MDC 06).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):DIG022 — Noninfectious gastroenteritis (default); INJ031 — Allergic reactions.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Contextual Map

Every relationship of K52.22 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • K00-K95 — Chapter 11: Diseases of the Digestive System (K00-K95) (K00-K95) [Hierarchy]
  • K50-K52 — Noninfective enteritis and colitis [Hierarchy]

Referenced by Excludes1 notes

  • T61 — Toxic effect of noxious substances eaten as seafood [Excludes1]: “food protein-induced enteropathy (K52.22)” · check together
  • T62 — Toxic effect of other noxious substances eaten as food [Excludes1]: “food protein-induced enteropathy (K52.22)” · check together
  • T78.4 — Other and unspecified allergy [Excludes1]: “food protein-induced enteropathy (K52.22)” · check together

Referenced by Excludes2 notes

  • T78.1 — Other adverse food reactions, not elsewhere classified [Excludes2]: “food protein-induced enteropathy (K52.22)” · check together

Clinical classification (CCSR)

  • DIG022 — Noninfectious gastroenteritis [CCSR]
  • INJ031 — Allergic reactions [CCSR]

Potential MS-DRG

  • DRG 391 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC [MS-DRG]: “ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC (MDC 06)”
  • DRG 392 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC [MS-DRG]: “ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC (MDC 06)”

MDC crossing · procedures (5744)

  • MDC 06 — Diseases and Disorders of the Digestive System [MDC crossing]: “Diseases and Disorders of the Digestive System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
  • 008Q0ZZ — Division of Vagus Nerve, Open Approach [Same-MDC procedure]: “Division of Vagus Nerve, Open Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q3ZZ — Division of Vagus Nerve, Percutaneous Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q4ZZ — Division of Vagus Nerve, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Endoscopic Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BP3ZZ — Excision of Pulmonary Trunk, Percutaneous Approach [Same-MDC procedure]: “Excision of Pulmonary Trunk, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BQ3ZZ — Excision of Right Pulmonary Artery, Percutaneous Approach [Same-MDC procedure]: “Excision of Right Pulmonary Artery, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • and 5739 more

Index entries

  • Allergy, allergic (reaction) (to), milk protein, enteropathy[Index term]
  • Enteritis (acute) (diarrheal) (hemorrhagic) (noninfective), allergic, with, food protein-induced enteropathy[Index term]
  • Enteropathy, food protein-induced[Index term]
  • Gastroenteritis (acute) (chronic) (noninfectious), allergic, with, food protein-induced enteropathy[Index term]

Nearest codes (17)

  • K52 — Other and unspecified noninfective gastroenteritis and colitis [Sibling]
  • K52.0 — Gastroenteritis and colitis due to radiation [Sibling]
  • K52.1 — Toxic gastroenteritis and colitis [Sibling]
  • K52.2 — Allergic and dietetic gastroenteritis and colitis [Sibling]
  • K52.21 — Food protein-induced enterocolitis syndrome [Sibling]
  • K52.29 — Other allergic and dietetic gastroenteritis and colitis [Sibling]
  • K52.3 — Indeterminate colitis [Sibling]
  • K52.8 — Other specified noninfective gastroenteritis and colitis [Sibling]
  • and 9 more

Change history

  • FY2017 — Added to the code set [Change history]

Nearest Codes in This Family

Official ICD-10-CM classifications closest to K52.22 in its code family, with their registry titles.

  • K52 — Other and unspecified noninfective gastroenteritis and colitis
  • K52.0 — Gastroenteritis and colitis due to radiation
  • K52.1 — Toxic gastroenteritis and colitis
  • K52.2 — Allergic and dietetic gastroenteritis and colitis
  • K52.21 — Food protein-induced enterocolitis syndrome
  • K52.29 — Other allergic and dietetic gastroenteritis and colitis
  • K52.3 — Indeterminate colitis
  • K52.8 — Other specified noninfective gastroenteritis and colitis
  • K52.81 — Eosinophilic gastritis or gastroenteritis
  • K52.82 — Eosinophilic colitis

View all codes in the K52 family