O99.281 is the authoritative medical code for Endocrine, nutritional and metabolic diseases complicating pregnancy, first trimester. This classification is used in medical billing and clinical recording to specify the clinical criteria for endocrine, nutritional and metabolic diseases complicating pregnancy, first trimester (ICD-10-CM O99.281), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Endocrine, nutritional and metabolic diseases complicating pregnancy, first trimester is a billable ICD-10-CM diagnosis code O99.281. Includes: conditions which complicate the pregnant state, are aggravated by the pregnancy or are a main reason for obstetric care. Excludes2 (not included here): diabetes mellitus O24.-; malnutrition O25.-; postpartum thyroiditis O90.5; when the reason for maternal care is that the condition is known or suspected to have affected the fetus O35-O36. Use additional code: code to identify specific condition.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for O99.281 in the official ICD-10-CM tabular list.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- conditions which complicate the pregnant state, are aggravated by the pregnancy or are a main reason for obstetric care
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- diabetes mellitus O24.-
- malnutrition O25.-
- postpartum thyroiditis O90.5
- when the reason for maternal care is that the condition is known or suspected to have affected the fetus O35-O36
Use Additional Code
Supplementary codes the tabular list directs you to add.
- code to identify specific condition
Frequently Asked Questions (FAQ) & Clinical Guidance
Can O99.281 be reported alongside related conditions?
Per Excludes2 instructions, O99.281 and the following may both be reported when both are present: diabetes mellitus (O24.-); malnutrition (O25.-); postpartum thyroiditis (O90.5); when the reason for maternal care is that the condition is known or suspected to have affected the fetus (O35-O36).
Is an additional code needed with O99.281?
Use additional code(s) to specify: code to identify specific condition.
Codes in This Family (40)
Official ICD-10-CM classifications in the same code family as O99.281, with their registry titles.
- O99 — Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
- O99.0 — Anemia complicating pregnancy, childbirth and the puerperium
- O99.01 — Anemia complicating pregnancy
- O99.011 — Anemia complicating pregnancy, first trimester
- O99.012 — Anemia complicating pregnancy, second trimester
- O99.013 — Anemia complicating pregnancy, third trimester
- O99.019 — Anemia complicating pregnancy, unspecified trimester
- O99.02 — Anemia complicating childbirth
- O99.03 — Anemia complicating the puerperium
- O99.1 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
- O99.11 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy
- O99.111 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, first trimester
- O99.112 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, second trimester
- O99.113 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, third trimester
- O99.119 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, unspecified trimester
- O99.12 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating childbirth
- O99.13 — Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating the puerperium
- O99.2 — Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
- O99.21 — Obesity complicating pregnancy, childbirth, and the puerperium
- O99.210 — Obesity complicating pregnancy, unspecified trimester
- O99.211 — Obesity complicating pregnancy, first trimester
- O99.212 — Obesity complicating pregnancy, second trimester
- O99.213 — Obesity complicating pregnancy, third trimester
- O99.214 — Obesity complicating childbirth
- O99.215 — Obesity complicating the puerperium
- O99.28 — Other endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
- O99.280 — Endocrine, nutritional and metabolic diseases complicating pregnancy, unspecified trimester
- O99.282 — Endocrine, nutritional and metabolic diseases complicating pregnancy, second trimester
- O99.283 — Endocrine, nutritional and metabolic diseases complicating pregnancy, third trimester
- O99.284 — Endocrine, nutritional and metabolic diseases complicating childbirth
- O99.285 — Endocrine, nutritional and metabolic diseases complicating the puerperium
- O99.3 — Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
- O99.31 — Alcohol use complicating pregnancy, childbirth, and the puerperium
- O99.310 — Alcohol use complicating pregnancy, unspecified trimester
- O99.311 — Alcohol use complicating pregnancy, first trimester
- O99.312 — Alcohol use complicating pregnancy, second trimester
- O99.313 — Alcohol use complicating pregnancy, third trimester
- O99.314 — Alcohol use complicating childbirth
- O99.315 — Alcohol use complicating the puerperium
- O99.32 — Drug use complicating pregnancy, childbirth, and the puerperium
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures: