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ICD-10/T50.915S

T50.915S ICD-10-CM Code: Adverse effect of multiple unspecified drugs, medicaments and biological substances, sequela

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 922 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITH MCC (MDC 21)
  • MS-DRG 923 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITHOUT MCC (MDC 21)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Adverse effect of multiple unspecified drugs, medicaments and biological substances, sequela is a billable ICD-10-CM diagnosis code (T50.915S).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T50.915S in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Code First

Underlying conditions that must be sequenced before this code.

  • Code first, for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Code Also

Additional codes that may be required to fully describe the encounter.

  • any specific drugs, medicaments and biological substances

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)

Change history

  • FY2020 — 2019-10-01
    Added to the code set
    Adverse effect of multiple unspecified drugs, medicaments and biological substances, sequela
    FY2020 changes

Verify Before Coding

  • Billable — reportable as written.
  • Principal-diagnosis restriction. The Medicare Code Editor lists this code as unacceptable as a principal diagnosis: it describes a circumstance influencing health status rather than a current illness or injury being treated. It is valid as a secondary diagnosis.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Referenced by Other Codes

Clinical classification (AHRQ CCSR):INJ075 — Poisoning/toxic effect/adverse effects/underdosing, sequela (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 922 (MDC 21), DRG 923 (MDC 21).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name T50.915S or its code family.

1 Excludes1 notes: T38 (via T50.9.-).

1 Use Additional Code instructions: G61.1 (via T50.-).

Frequently Asked Questions (FAQ) & Clinical Guidance

Does T50.915S require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T50.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T50.915S in its code family, with their registry titles.

  • T50.914D — Poisoning by multiple unspecified drugs, medicaments and biological substances, undetermined, subsequent encounter
  • T50.914S — Poisoning by multiple unspecified drugs, medicaments and biological substances, undetermined, sequela
  • T50.915 — Adverse effect of multiple unspecified drugs, medicaments and biological substances
  • T50.915A — Adverse effect of multiple unspecified drugs, medicaments and biological substances, initial encounter
  • T50.915D — Adverse effect of multiple unspecified drugs, medicaments and biological substances, subsequent encounter
  • T50.916 — Underdosing of multiple unspecified drugs, medicaments and biological substances
  • T50.916A — Underdosing of multiple unspecified drugs, medicaments and biological substances, initial encounter
  • T50.916D — Underdosing of multiple unspecified drugs, medicaments and biological substances, subsequent encounter
  • T50.916S — Underdosing of multiple unspecified drugs, medicaments and biological substances, sequela
  • T50.99 — Poisoning by, adverse effect of and underdosing of other drugs, medicaments and biological substances

View all codes in the T50 family

Associated Substances (1)

Substances from the official ICD-10-CM Table of Drugs and Chemicals that map to this code.

  • Multiple unspecified drugs, medicaments and biological substances