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B20 vs D89.41

B20 (Human immunodeficiency virus [HIV] disease) compared with D89.41 (Monoclonal mast cell activation syndrome), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).

Relationship

Informational

Excludes2 relationship

D89.41
Monoclonal mast cell activation syndrome
B20
Human immunodeficiency virus [HIV] disease

Distinct conditions — both may be reported.

“human immunodeficiency virus [HIV] disease (B20)”

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source: CMS ICD-10-CM tabular instructional notes

Can these codes be reported together?

Yes, when both are documented. D89.41 carries an Excludes2 note covering B20: “human immunodeficiency virus [HIV] disease (B20)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

B20Human immunodeficiency virus [HIV] diseaseD89.41Monoclonal mast cell activation syndrome
Billing statusBillableBillable
ClassificationA00-B99 — Certain Infectious and Parasitic Diseases (A00-B99)D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)
DefinitionHuman immunodeficiency virus [HIV] disease is a billable ICD-10-CM diagnosis code (B20).Monoclonal mast cell activation syndrome is a billable ICD-10-CM diagnosis code (D89.41).
Includes
acquired immune deficiency syndrome [AIDS]
AIDS-related complex [ARC]
HIV infection, symptomatic
defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
sarcoidosis
Use additional code
code(s) to identify all manifestations of HIV infection
Code first
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources