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C22.8 vs D13.4

C22.8 (Malignant neoplasm of liver, primary, unspecified as to type) compared with D13.4 (Benign neoplasm of liver), from the official CMS tabular data. C22.8 and D13.4 name the same anatomical site (hepatic) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

C22.8
Malignant neoplasm of liver, primary, unspecified as to type
D13.4
Benign neoplasm of liver

Same anatomical site, different neoplasm behavior.

Same site — benign neoplasm (hepatic)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. C22.8 and D13.4 name the same anatomical site (hepatic) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

C22.8Malignant neoplasm of liver, primary, unspecified as to typeD13.4Benign neoplasm of liver
Billing statusBillableBillable
ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionMalignant neoplasm of liver, primary, unspecified as to type is a billable ICD-10-CM diagnosis code (C22.8).Benign neoplasm of liver is a billable ICD-10-CM diagnosis code (D13.4).
Includes
Benign neoplasm of intrahepatic bile ducts
Use additional code
code to identify:
alcohol abuse and dependence (F10.-)
hepatitis B (B16.-, B18.0-B18.1)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources