C46.3 (Kaposi's sarcoma of lymph nodes) compared with C81.21 (Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).
Distinct conditions — both may be reported.
“Kaposi's sarcoma of lymph nodes (C46.3)”
An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.
Source: CMS ICD-10-CM tabular instructional notes
Yes, when both are documented. C81.21 carries an Excludes2 note covering C46.3: “Kaposi's sarcoma of lymph nodes (C46.3)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
| C46.3Kaposi's sarcoma of lymph nodes | C81.21Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | C00-D49 — Neoplasms (C00-D49) | C00-D49 — Neoplasms (C00-D49) |
| Definition | Kaposi's sarcoma of lymph nodes is a billable ICD-10-CM diagnosis code (C46.3). | Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck is a billable ICD-10-CM diagnosis code (C81.21). |
| Code first | any human immunodeficiency virus [HIV] disease (B20) | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources