C48.0 vs C49
C48.0 (Malignant neoplasm of retroperitoneum) compared with C49 (Malignant neoplasm of other connective and soft tissue), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).
Can these codes be reported together?
Yes, when both are documented. C49 carries an Excludes2 note covering C48.0: “malignant neoplasm of retroperitoneum (C48.0)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
Side by side
| C48.0Malignant neoplasm of retroperitoneum | C49Malignant neoplasm of other connective and soft tissue | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | C00-D49 — Neoplasms (C00-D49) | C00-D49 — Neoplasms (C00-D49) |
| Definition | Malignant neoplasm of retroperitoneum is a billable ICD-10-CM diagnosis code (C48.0). | Malignant neoplasm of other connective and soft tissue is a non-billable ICD-10-CM category code (C49). |
| Includes | — | malignant neoplasm of blood vessel malignant neoplasm of bursa malignant neoplasm of cartilage malignant neoplasm of fascia |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources