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C48.0 vs C49.A1

C48.0 (Malignant neoplasm of retroperitoneum) compared with C49.A1 (Gastrointestinal stromal tumor of esophagus), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).

Can these codes be reported together?

Yes, when both are documented. C49.A1 carries an Excludes2 note covering C48.0: “malignant neoplasm of retroperitoneum (C48.0)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

C48.0Malignant neoplasm of retroperitoneumC49.A1Gastrointestinal stromal tumor of esophagus
Billing statusBillableBillable
ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionMalignant neoplasm of retroperitoneum is a billable ICD-10-CM diagnosis code (C48.0).Gastrointestinal stromal tumor of esophagus is a billable ICD-10-CM diagnosis code (C49.A1).
Includes
malignant neoplasm of blood vessel
malignant neoplasm of bursa
malignant neoplasm of cartilage
malignant neoplasm of fascia

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources