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C48.0 vs D49.0

C48.0 (Malignant neoplasm of retroperitoneum) compared with D49.0 (Neoplasm of unspecified behavior of digestive system), from the official CMS tabular data. C48.0 and D49.0 name the same anatomical site (connective tissue) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

C48.0
Malignant neoplasm of retroperitoneum
D49.0
Neoplasm of unspecified behavior of digestive system

Same anatomical site, different neoplasm behavior.

Same site — unspecified behavior (connective tissue)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. C48.0 and D49.0 name the same anatomical site (connective tissue) with a different neoplasm behavior.

From the CMS Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

C48.0Malignant neoplasm of retroperitoneumD49.0Neoplasm of unspecified behavior of digestive system
Billing statusBillableBillable
ClassificationC00-D49 — NeoplasmsC00-D49 — Neoplasms
DefinitionMalignant neoplasm of retroperitoneum is a billable ICD-10-CM diagnosis code (C48.0).Neoplasm of unspecified behavior of digestive system is a billable ICD-10-CM diagnosis code (D49.0).
Includes
'growth' NOS
neoplasm NOS
new growth NOS
tumor NOS

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources