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C48.1 vs D48.4

C48.1 (Malignant neoplasm of specified parts of peritoneum) compared with D48.4 (Neoplasm of uncertain behavior of peritoneum), from the official CMS tabular data. C48.1 and D48.4 name the same anatomical site (cul-de-sac) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

C48.1
Malignant neoplasm of specified parts of peritoneum
D48.4
Neoplasm of uncertain behavior of peritoneum

Same anatomical site, different neoplasm behavior.

Same site — uncertain behavior (cul-de-sac)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. C48.1 and D48.4 name the same anatomical site (cul-de-sac) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

C48.1Malignant neoplasm of specified parts of peritoneumD48.4Neoplasm of uncertain behavior of peritoneum
Billing statusBillableBillable
ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionMalignant neoplasm of specified parts of peritoneum is a billable ICD-10-CM diagnosis code (C48.1).Neoplasm of uncertain behavior of peritoneum is a billable ICD-10-CM diagnosis code (D48.4).
Includes
Malignant neoplasm of cul-de-sac
Malignant neoplasm of mesentery
Malignant neoplasm of mesocolon
Malignant neoplasm of omentum

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources