C49 vs C50
C49 (Malignant neoplasm of other connective and soft tissue) compared with C50 (Malignant neoplasm of breast), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. C49 carries an Excludes1 note covering C50: “malignant neoplasm of connective tissue of breast (C50.-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| C49Malignant neoplasm of other connective and soft tissue | C50Malignant neoplasm of breast | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | C00-D49 — Neoplasms (C00-D49) | C00-D49 — Neoplasms (C00-D49) |
| Definition | Malignant neoplasm of other connective and soft tissue is a non-billable ICD-10-CM category code (C49). | Malignant neoplasm of breast is a non-billable ICD-10-CM category code (C50). |
| Includes | malignant neoplasm of blood vessel malignant neoplasm of bursa malignant neoplasm of cartilage malignant neoplasm of fascia | connective tissue of breast Paget's disease of breast Paget's disease of nipple |
| Use additional code | — | code to identify estrogen, and other hormones and factors receptor status (Z17.-) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources