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C50.3 vs D49.3

C50.3 (Malignant neoplasm of lower-inner quadrant of breast) compared with D49.3 (Neoplasm of unspecified behavior of breast), from the official CMS tabular data. C50.3 and D49.3 name the same anatomical site (breast) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

C50.3
Malignant neoplasm of lower-inner quadrant of breast
D49.3
Neoplasm of unspecified behavior of breast

Same anatomical site, different neoplasm behavior.

Same site — unspecified behavior (breast)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. C50.3 and D49.3 name the same anatomical site (breast) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

C50.3Malignant neoplasm of lower-inner quadrant of breastD49.3Neoplasm of unspecified behavior of breast
Billing statusNon-billable header

Report instead: C50.311, C50.312, C50.319, C50.321, C50.322

Billable
ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionMalignant neoplasm of lower-inner quadrant of breast is a non-billable ICD-10-CM category code (C50.3).Neoplasm of unspecified behavior of breast is a billable ICD-10-CM diagnosis code (D49.3).
Includes
connective tissue of breast
Paget's disease of breast
Paget's disease of nipple
'growth' NOS
neoplasm NOS
new growth NOS
tumor NOS
Use additional code
code to identify estrogen, and other hormones and factors receptor status (Z17.-)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources