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C50.8 vs C79.81

C50.8 (Malignant neoplasm of overlapping sites of breast) compared with C79.81 (Secondary malignant neoplasm of breast), from the official CMS tabular data. C50.8 and C79.81 name the same anatomical site (breast) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

C50.8
Malignant neoplasm of overlapping sites of breast
C79.81
Secondary malignant neoplasm of breast

Same anatomical site, different neoplasm behavior.

Same site — secondary malignancy (breast)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. C50.8 and C79.81 name the same anatomical site (breast) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

C50.8Malignant neoplasm of overlapping sites of breastC79.81Secondary malignant neoplasm of breast
Billing statusNon-billable header

Report instead: C50.811, C50.812, C50.819, C50.821, C50.822

Billable
ClassificationC00-D49 — NeoplasmsC00-D49 — Neoplasms
DefinitionMalignant neoplasm of overlapping sites of breast is a non-billable ICD-10-CM category code (C50.8).Secondary malignant neoplasm of breast is a billable ICD-10-CM diagnosis code (C79.81).
Includes
connective tissue of breast
Paget's disease of breast
Paget's disease of nipple
Use additional code
code to identify estrogen, and other hormones and factors receptor status (Z17.-)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources