C57.8 vs D49.59

C57.8 (Malignant neoplasm of overlapping sites of female genital organs) compared with D49.59 (Neoplasm of unspecified behavior of other genitourinary organ), from the official CMS tabular data. C57.8 and D49.59 name the same anatomical site (tubo-ovarian) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

D49.59

Neoplasm of unspecified behavior of other genitourinary organ

↔

C57.8

Malignant neoplasm of overlapping sites of female genital organs

Same anatomical site, different neoplasm behavior.

Same site — primary malignancy (tubo-ovarian)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. D49.59 and C57.8 name the same anatomical site (tubo-ovarian) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

	C57.8Malignant neoplasm of overlapping sites of female genital organs	D49.59Neoplasm of unspecified behavior of other genitourinary organ
Billing status	Billable	Billable
Classification	C00-D49 — Neoplasms	C00-D49 — Neoplasms
Definition	Malignant neoplasm of overlapping sites of female genital organs is a billable ICD-10-CM diagnosis code (C57.8).	Neoplasm of unspecified behavior of other genitourinary organ is a billable ICD-10-CM diagnosis code (D49.59).
Includes	malignant neoplasm of skin of female genital organs Primary malignant neoplasm of two or more contiguous sites of the female genital organs whose point of origin cannot be determined Primary tubo-ovarian malignant neoplasm whose point of origin cannot be determined Primary utero-ovarian malignant neoplasm whose point of origin cannot be determined	'growth' NOS neoplasm NOS new growth NOS tumor NOS

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources