C61 (Malignant neoplasm of prostate) compared with D49.59 (Neoplasm of unspecified behavior of other genitourinary organ), from the official CMS tabular data. C61 and D49.59 name the same anatomical site (prostate) with a different neoplasm behavior. MedCoder-derived
Same anatomical site, different neoplasm behavior.
Same site — primary malignancy (prostate)
The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.
Source: CMS Table of Neoplasms
Same site, different neoplasm behavior. D49.59 and C61 name the same anatomical site (prostate) with a different neoplasm behavior.
From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.
| C61Malignant neoplasm of prostate | D49.59Neoplasm of unspecified behavior of other genitourinary organ | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | C00-D49 — Neoplasms | C00-D49 — Neoplasms |
| Definition | Malignant neoplasm of prostate is a billable ICD-10-CM diagnosis code (C61). | Neoplasm of unspecified behavior of other genitourinary organ is a billable ICD-10-CM diagnosis code (D49.59). |
| Includes | malignant neoplasm of skin of male genital organs | 'growth' NOS neoplasm NOS new growth NOS tumor NOS |
| Use additional code | code, if applicable, to identify: hormone sensitivity status (Z19.1-Z19.2) rising PSA following treatment for malignant neoplasm of prostate (R97.21) | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources