C78.89 (Secondary malignant neoplasm of other digestive organs) compared with C81.21 (Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).
Distinct conditions — both may be reported.
“secondary neoplasm of spleen (C78.89)”
An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.
Source: CMS ICD-10-CM tabular instructional notes
Yes, when both are documented. C81.21 carries an Excludes2 note covering C78.89: “secondary neoplasm of spleen (C78.89)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
| C78.89Secondary malignant neoplasm of other digestive organs | C81.21Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | C00-D49 — Neoplasms (C00-D49) | C00-D49 — Neoplasms (C00-D49) |
| Definition | Secondary malignant neoplasm of other digestive organs is a billable ICD-10-CM diagnosis code (C78.89). | Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck is a billable ICD-10-CM diagnosis code (C81.21). |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources