C94.0 vs D53.1
C94.0 (Acute erythroid leukemia) compared with D53.1 (Other megaloblastic anemias, not elsewhere classified), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. D53.1 carries an Excludes1 note covering C94.0: “Di Guglielmo's disease (C94.0)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| C94.0Acute erythroid leukemia | D53.1Other megaloblastic anemias, not elsewhere classified | |
|---|---|---|
| Billing status | Non-billable header | Billable |
| Classification | C00-D49 — Neoplasms (C00-D49) | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) |
| Definition | Acute erythroid leukemia is a non-billable ICD-10-CM category code (C94.0). | Other megaloblastic anemias, not elsewhere classified is a billable ICD-10-CM diagnosis code (D53.1). |
| Includes | Acute myeloid leukemia M6(a)(b) Erythroleukemia | megaloblastic anemia unresponsive to vitamin B12 or folate therapy Megaloblastic anemia NOS |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources