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Compare/D16 vs D21

D16 vs D21

D16 (Benign neoplasm of bone and articular cartilage) compared with D21 (Other benign neoplasms of connective and other soft tissue), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. D16 carries an Excludes1 note covering D21: “benign neoplasm of synovia (D21.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

No — do not report together. D21 carries an Excludes1 note covering D16: “benign neoplasm of articular cartilage (D16.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

D16Benign neoplasm of bone and articular cartilageD21Other benign neoplasms of connective and other soft tissue
Billing statusNon-billable header

Report instead: D16.00, D16.01, D16.02, D16.10, D16.11

Non-billable header

Report instead: D21.0, D21.10, D21.11, D21.12, D21.20

ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionBenign neoplasm of bone and articular cartilage is a non-billable ICD-10-CM category code (D16).Other benign neoplasms of connective and other soft tissue is a non-billable ICD-10-CM category code (D21).
Includes
benign neoplasm of blood vessel
benign neoplasm of bursa
benign neoplasm of cartilage
benign neoplasm of fascia

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources