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D21.0 vs Z85.22

D21.0 (Benign neoplasm of connective and other soft tissue of head, face and neck) compared with Z85.22 (Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses), from the official CMS tabular data. Z85.22 is the personal-history/screening code for the active disease D21.0 names. MedCoder-derived

Relationship

Review

Condition lifecycle relationship

Z85.22
Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
↔
D21.0
Benign neoplasm of connective and other soft tissue of head, face and neck

Personal-history or screening code versus the active disease.

Benign neoplasm of this site (ear)

A personal-history code describes a condition that no longer exists and is no longer being treated, so it is not interchangeable with the active-disease code for the same site.

Source: CMS Table of Neoplasms (site match derived from the code title)

Can these codes be reported together?

History or screening versus active disease. Z85.22 is the personal-history or screening code for the active disease D21.0 names.

Site match derived from the code’s own title against the CMS/CDC Table of Neoplasms. A personal-history code describes a condition that no longer exists and is no longer being treated, so it is not interchangeable with the active-disease code.

Side by side

D21.0Benign neoplasm of connective and other soft tissue of head, face and neckZ85.22Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
Billing statusBillableBillable
ClassificationC00-D49 — NeoplasmsZ00-Z99 — Factors influencing health status and contact with health services
DefinitionBenign neoplasm of connective and other soft tissue of head, face and neck is a billable ICD-10-CM diagnosis code (D21.0).Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses is a billable ICD-10-CM diagnosis code (Z85.22).
Includes
benign neoplasm of blood vessel
benign neoplasm of bursa
benign neoplasm of cartilage
benign neoplasm of fascia
Conditions classifiable to C30-C31
Use additional code—
code to identify:
alcohol use and dependence (F10.-)
exposure to environmental tobacco smoke (Z77.22)
Code first—
any follow-up examination after treatment of malignant neoplasm (Z08)
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources