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D48 vs D49.51

D48 (Neoplasm of uncertain behavior of other and unspecified sites) compared with D49.51 (Neoplasm of unspecified behavior of kidney), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. D48 carries an Excludes1 note covering D49.51: “neoplasms of unspecified behavior (D49.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Yes, when both are documented. D49.51 carries an Excludes2 note covering D48: “neoplasms of uncertain behavior (D37-D44, D48)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

D48Neoplasm of uncertain behavior of other and unspecified sitesD49.51Neoplasm of unspecified behavior of kidney
Billing statusNon-billable header

Report instead: D48.0, D48.110, D48.111, D48.112, D48.113

Non-billable header
ClassificationC00-D49 — Neoplasms (C00-D49)C00-D49 — Neoplasms (C00-D49)
DefinitionNeoplasm of uncertain behavior of other and unspecified sites is a non-billable ICD-10-CM category code (D48).Neoplasm of unspecified behavior of kidney is a non-billable ICD-10-CM category code (D49.51).
Includes
'growth' NOS
neoplasm NOS
new growth NOS
tumor NOS

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources