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D55 vs E76

D55 (Anemia due to enzyme disorders) compared with E76 (Disorders of glycosaminoglycan metabolism), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. E76 carries an Excludes1 note covering D55: “hemolytic anemias attributable to enzyme disorders (D55.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

D55Anemia due to enzyme disordersE76Disorders of glycosaminoglycan metabolism
Billing statusNon-billable header

Report instead: D55.0, D55.1, D55.21, D55.29, D55.3

Non-billable header

Report instead: E76.01, E76.02, E76.03, E76.1, E76.210

ClassificationD50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)
DefinitionAnemia due to enzyme disorders is a non-billable ICD-10-CM category code (D55).Disorders of glycosaminoglycan metabolism is a non-billable ICD-10-CM category code (E76).
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources