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D56.0 vs D56.3

D56.0 (Alpha thalassemia) compared with D56.3 (Thalassemia minor), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. D56.0 carries an Excludes1 note covering D56.3: “alpha thalassemia trait or minor (D56.3)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

No — do not report together. D56.0 carries an Excludes1 note covering D56.3: “asymptomatic alpha thalassemia (D56.3)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

No — do not report together. D56.3 carries an Excludes1 note covering D56.0: “alpha thalassemia (D56.0)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

D56.0Alpha thalassemiaD56.3Thalassemia minor
Billing statusBillableBillable
ClassificationD50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)
DefinitionAlpha thalassemia is a billable ICD-10-CM diagnosis code (D56.0).Thalassemia minor is a billable ICD-10-CM diagnosis code (D56.3).
Includes
Alpha thalassemia major
Hemoglobin H Constant Spring
Hemoglobin H disease
Hydrops fetalis due to alpha thalassemia
Alpha thalassemia minor
Alpha thalassemia silent carrier
Alpha thalassemia trait
Beta thalassemia minor
Use additional code
code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources