D56.3 vs D57.3
D56.3 (Thalassemia minor) compared with D57.3 (Sickle-cell trait), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. D56.3 carries an Excludes1 note covering D57.3: “sickle-cell trait (D57.3)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| D56.3Thalassemia minor | D57.3Sickle-cell trait | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) |
| Definition | Thalassemia minor is a billable ICD-10-CM diagnosis code (D56.3). | Sickle-cell trait is a billable ICD-10-CM diagnosis code (D57.3). |
| Includes | Alpha thalassemia minor Alpha thalassemia silent carrier Alpha thalassemia trait Beta thalassemia minor | Hb-S trait Heterozygous hemoglobin S |
| Use additional code | — | code for any associated fever (R50.81) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources