D64.3 vs E53.1
D64.3 (Other sideroblastic anemias) compared with E53.1 (Pyridoxine deficiency), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E53.1 carries an Excludes1 note covering D64.3: “pyridoxine-responsive sideroblastic anemia (D64.3)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| D64.3Other sideroblastic anemias | E53.1Pyridoxine deficiency | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Other sideroblastic anemias is a billable ICD-10-CM diagnosis code (D64.3). | Pyridoxine deficiency is a billable ICD-10-CM diagnosis code (E53.1). |
| Includes | Sideroblastic anemia NOS Pyridoxine-responsive sideroblastic anemia NEC | Vitamin B6 deficiency |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources