E22 vs E24.0
E22 (Hyperfunction of pituitary gland) compared with E24.0 (Pituitary-dependent Cushing's disease), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E22 carries an Excludes1 note covering E24.0: “Cushing's syndrome (E24.-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
No — do not report together. E22 carries an Excludes1 note covering E24.0: “overproduction of pituitary ACTH (E24.0)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E22Hyperfunction of pituitary gland | E24.0Pituitary-dependent Cushing's disease | |
|---|---|---|
| Billing status | Non-billable header | Billable |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Hyperfunction of pituitary gland is a non-billable ICD-10-CM category code (E22). | Pituitary-dependent Cushing's disease is a billable ICD-10-CM diagnosis code (E24.0). |
| Includes | — | Overproduction of pituitary ACTH Pituitary-dependent hypercorticalism |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources