E31.2 vs Z15.81
E31.2 (Multiple endocrine neoplasia [MEN] syndromes) compared with Z15.81 (Genetic susceptibility to multiple endocrine neoplasia [MEN]), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. Z15.81 carries an Excludes1 note covering E31.2: “multiple endocrine neoplasia [MEN] syndromes (E31.2-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E31.2Multiple endocrine neoplasia [MEN] syndromes | Z15.81Genetic susceptibility to multiple endocrine neoplasia [MEN] | |
|---|---|---|
| Billing status | Non-billable header | Billable |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | Z00-Z99 — Factors Influencing Health Status and Contact with Health Services (Z00-Z99) |
| Definition | Multiple endocrine neoplasia [MEN] syndromes is a non-billable ICD-10-CM category code (E31.2). | Genetic susceptibility to multiple endocrine neoplasia [MEN] is a billable ICD-10-CM diagnosis code (Z15.81). |
| Includes | Multiple endocrine adenomatosis | confirmed abnormal gene |
| Use additional code | — | code, if applicable, for any associated family history of the disease (Z80-Z84) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources