E72.20 vs P74.6
E72.20 (Disorder of urea cycle metabolism, unspecified) compared with P74.6 (Transitory hyperammonemia of newborn), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E72.20 carries an Excludes1 note covering P74.6: “transient hyperammonemia of newborn (P74.6)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E72.20Disorder of urea cycle metabolism, unspecified | P74.6Transitory hyperammonemia of newborn | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | P00-P96 — Certain Conditions Originating in the Perinatal Period (P00-P96) |
| Definition | Disorder of urea cycle metabolism, unspecified is a billable ICD-10-CM diagnosis code (E72.20). | Transitory hyperammonemia of newborn is a billable ICD-10-CM diagnosis code (P74.6). |
| Includes | Hyperammonemia | transitory endocrine and metabolic disturbances caused by the infant's response to maternal endocrine and metabolic factors, or its adjustment to extrauterine environment |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources