E85.0 vs E85.4
E85.0 (Non-neuropathic heredofamilial amyloidosis) compared with E85.4 (Organ-limited amyloidosis), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).
Can these codes be reported together?
Yes, when both are documented. E85.0 carries an Excludes2 note covering E85.4: “Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
Side by side
| E85.0Non-neuropathic heredofamilial amyloidosis | E85.4Organ-limited amyloidosis | |
|---|---|---|
| Billing status | Billable | Billable |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Non-neuropathic heredofamilial amyloidosis is a billable ICD-10-CM diagnosis code (E85.0). | Organ-limited amyloidosis is a billable ICD-10-CM diagnosis code (E85.4). |
| Includes | Hereditary amyloid nephropathy | Localized amyloidosis Transthyretin-related (ATTR) familial amyloid cardiomyopathy |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources