E88.4 vs H49.81
E88.4 (Mitochondrial metabolism disorders) compared with H49.81 (Kearns-Sayre syndrome), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E88.4 carries an Excludes1 note covering H49.81: “Kearns-Sayre syndrome (H49.81)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E88.4Mitochondrial metabolism disorders | H49.81Kearns-Sayre syndrome | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | H00-H59 — Diseases of the Eye and Adnexa (H00-H59) |
| Definition | Mitochondrial metabolism disorders is a non-billable ICD-10-CM category code (E88.4). | Kearns-Sayre syndrome is a non-billable ICD-10-CM category code (H49.81). |
| Includes | — | Progressive external ophthalmoplegia with pigmentary retinopathy |
| Use additional code | codes for associated conditions | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources