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H16.22 vs M35.01

H16.22 (Keratoconjunctivitis sicca, not specified as Sjögren's) compared with M35.01 (Sjögren syndrome with keratoconjunctivitis), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. H16.22 carries an Excludes1 note covering M35.01: “Sjögren's syndrome (M35.01)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

H16.22Keratoconjunctivitis sicca, not specified as Sjögren'sM35.01Sjögren syndrome with keratoconjunctivitis
Billing statusNon-billable header

Report instead: H16.221, H16.222, H16.223, H16.229

Billable
ClassificationH00-H59 — Diseases of the Eye and Adnexa (H00-H59)M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)
DefinitionKeratoconjunctivitis sicca, not specified as Sjögren's is a non-billable ICD-10-CM category code (H16.22).Sjögren syndrome with keratoconjunctivitis is a billable ICD-10-CM diagnosis code (M35.01).
Includes
autoimmune disease NOS
collagen (vascular) disease NOS
systemic autoimmune disease
systemic collagen (vascular) disease
Use additional code
code to identify associated manifestations

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources