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I21 vs I74

I21 (Acute myocardial infarction) compared with I74 (Arterial embolism and thrombosis), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).

Can these codes be reported together?

Yes, when both are documented. I74 carries an Excludes2 note covering I21: “coronary embolism and thrombosis (I21-I25)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

I21Acute myocardial infarctionI74Arterial embolism and thrombosis
Billing statusNon-billable header

Report instead: I21.01, I21.02, I21.09, I21.11, I21.19

Non-billable header

Report instead: I74.01, I74.09, I74.10, I74.11, I74.19

ClassificationI00-I99 — Diseases of the Circulatory System (I00-I99)I00-I99 — Diseases of the Circulatory System (I00-I99)
DefinitionAcute myocardial infarction is a non-billable ICD-10-CM category code (I21).Arterial embolism and thrombosis is a non-billable ICD-10-CM category code (I74).
Includes
cardiac infarction
coronary (artery) embolism
coronary (artery) occlusion
coronary (artery) rupture
embolic infarction
embolic occlusion
thrombotic infarction
thrombotic occlusion
Use additional code
code, if applicable, to identify:
exposure to environmental tobacco smoke (Z77.22)
history of tobacco dependence (Z87.891)
—
Code first—
embolism and thrombosis complicating abortion or ectopic or molar pregnancy (O00-O07, O08.2)
embolism and thrombosis complicating pregnancy, childbirth and the puerperium (O88.-)
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources