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M35.04 vs N16

M35.04 (Sjögren syndrome with tubulo-interstitial nephropathy) compared with N16 (Renal tubulo-interstitial disorders in diseases classified elsewhere), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. N16 carries an Excludes1 note covering M35.04: “pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

M35.04Sjögren syndrome with tubulo-interstitial nephropathyN16Renal tubulo-interstitial disorders in diseases classified elsewhere
Billing statusBillableBillable
ClassificationM00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)N00-N99 — Diseases of the Genitourinary System (N00-N99)
DefinitionSjögren syndrome with tubulo-interstitial nephropathy is a billable ICD-10-CM diagnosis code (M35.04).Renal tubulo-interstitial disorders in diseases classified elsewhere is a billable ICD-10-CM diagnosis code (N16).
Includes
autoimmune disease NOS
collagen (vascular) disease NOS
systemic autoimmune disease
systemic collagen (vascular) disease
pyelonephritis
Pyelonephritis
Tubulo-interstitial nephritis
Use additional code
code to identify associated manifestations
Code first
underlying disease, such as:
brucellosis (A23.0-A23.9)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources