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P00 vs T43.22

P00 (Newborn affected by maternal conditions that may be unrelated to present pregnancy) compared with T43.22 (Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors), from the official CMS tabular data.

Summary

These codes can be reported together when both conditions are documented, because T43.22 lists P00 under Excludes2, which marks them as distinct conditions.

Official rule
What is different?

The conditions named and chapter.P00 is “Newborn affected by maternal conditions that may be unrelated to present pregnancy”; T43.22 is “Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors”. P00 sits in P00-P96 — Certain Conditions Originating in the Perinatal Period (P00-P96); T43.22 in S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88).

Registry fact

Can these codes be reported together?

Yes, when both are documented.T43.22 lists P00 under Excludes2: “drug reaction and poisoning affecting newborn (P00-P96)”. Excludes2 marks distinct conditions that may both be reported when both are documented.

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. T43.22 carries 1 Excludes1 note covering other codes; the side-by-side table quotes them.

Official rule

Is there an Excludes2 relationship?

Yes.T43.22’s tabular entry: “drug reaction and poisoning affecting newborn (P00-P96)”. The note covers P00.

Official ruleGuide: Excludes1 vs Excludes2

Is one more specific?

Not comparable.The codes sit in different categories; specificity is only comparable within one category.

Is one a parent or header code?

Both are headers.Both are non-billable headers, and neither contains the other.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Informational

Excludes2 relationship

T43.22
Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors
↔
P00
Newborn affected by maternal conditions that may be unrelated to present pregnancy

What we found

Yes, when both are documented.T43.22 carries an Excludes2 note covering P00: “drug reaction and poisoning affecting newborn (P00-P96)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

What to review

Report both only when the documentation supports both conditions; otherwise report the one documented.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source / rule

CMS ICD-10-CM tabular instructional notes

Official guidance behind these answers

  • Section I.A.12.b — Excludes2 · applies to: Excludes2

    A type 2 Excludes note represents “Not included here.” An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

    ICD-10-CM Official Guidelines FY2026

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

P00Newborn affected by maternal conditions that may be unrelated to present pregnancyT43.22Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors
Billing statusNon-billable header

Report instead: P00.0, P00.1, P00.2, P00.3, P00.4

Non-billable header

Report instead: T43.221A, T43.221D, T43.221S, T43.222A, T43.222D

ClassificationP00-P96 — Certain Conditions Originating in the Perinatal Period (P00-P96)S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
DefinitionNewborn affected by maternal conditions that may be unrelated to present pregnancy is a non-billable ICD-10-CM category code (P00).Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors is a non-billable ICD-10-CM category code (T43.22).
7th character—The appropriate 7th character is to be added to each code from category T43
Includes—
adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1—
toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
encounter for observation of newborn for suspected diseases and conditions ruled out (Z05.-)
newborn affected by maternal complications of pregnancy (P01.-)
newborn affected by maternal endocrine and metabolic disorders (P70-P74)
newborn affected by noxious substances transmitted via placenta or breast milk (P04.-)
appetite depressants (T50.5-)
barbiturates (T42.3-)
benzodiazepines (T42.4-)
drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-)
methaqualone (T42.6-)
psychodysleptics [hallucinogens] (T40.7-T40.9-)
abuse and dependence of psychoactive substances (F10-F19)
abuse of non-dependence-producing substances (F55.-)
immunodeficiency due to drugs (D84.821)
drug reaction and poisoning affecting newborn (P00-P96)
pathological drug intoxication (inebriation) (F10-F19)
Code first
any current condition in newborn
, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)
Use additional code—
code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on.

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Derived from the official CMS ICD-10-CM tabular data (FY2026). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources