R65.1 vs R65.2
R65.1 (Systemic inflammatory response syndrome (SIRS) of non-infectious origin) compared with R65.2 (Severe sepsis), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. R65.1 carries an Excludes1 note covering R65.2: “severe sepsis (R65.2)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious origin | R65.2Severe sepsis | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99) | R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99) |
| Definition | Systemic inflammatory response syndrome (SIRS) of non-infectious origin is a non-billable ICD-10-CM category code (R65.1). | Severe sepsis is a non-billable ICD-10-CM category code (R65.2). |
| Includes | — | Infection with associated acute organ dysfunction Sepsis with acute organ dysfunction Sepsis with multiple organ dysfunction Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction |
| Use additional code | — | code to identify specific acute organ dysfunction, such as: acute kidney failure (N17.-) acute respiratory failure (J96.0-) |
| Code first | underlying condition, such as: heatstroke (T67.0-) | underlying infection, such as: infection following a procedure (T81.4-) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources