T39.395 vs T39.396

T39.395 (Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID]) compared with T39.396 (Underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]), from the official CMS tabular data. T39.395 and T39.396 code the same substance (Anti-inflammatory) with a different intent.

Relationship

Informational

Drug table relationship

T39.395

Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID]

↔

T39.396

Underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]

Same substance, different circumstance of exposure.

Same substance — underdosing (Anti-inflammatory)

Accidental poisoning, intentional self-harm, assault, undetermined intent, adverse effect and underdosing are mutually exclusive columns — exactly one applies to a given encounter.

Source: CMS Table of Drugs and Chemicals

Can these codes be reported together?

Same substance, different intent. T39.395 and T39.396 code the same substance (Anti-inflammatory) with a different circumstance of exposure.

From the CMS Table of Drugs and Chemicals: accidental poisoning, intentional self-harm, assault, undetermined intent, adverse effect and underdosing are mutually exclusive columns — only one of them applies to a given encounter.

Side by side

	T39.395Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID]	T39.396Underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]
Billing status	Non-billable header	Non-billable header
Classification	S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)	S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
Definition	Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID] is a non-billable ICD-10-CM category code (T39.395).	Underdosing of other nonsteroidal anti-inflammatory drugs [NSAID] is a non-billable ICD-10-CM category code (T39.396).
7th character	The appropriate 7th character is to be added to each code from category T39	The appropriate 7th character is to be added to each code from category T39
Includes	adverse effect of correct substance properly administered poisoning by overdose of substance poisoning by wrong substance given or taken in error underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed	adverse effect of correct substance properly administered poisoning by overdose of substance poisoning by wrong substance given or taken in error underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Use additional code	code(s) to specify: manifestations of poisoning underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)	code(s) to specify: manifestations of poisoning underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
Code first	, for adverse effects, the nature of the adverse effect, such as: adverse effect NOS (T88.7)	, for adverse effects, the nature of the adverse effect, such as: adverse effect NOS (T88.7)

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources